NEUROGENETICS AND BEHAVIOR CENTER:ANIMAL TEST FACIL:AIDS

描述（由申请人提供）： 在该奖项的支持下，神经遗传学和行为中心将为 NIH 支持的研究项目建立独特的资源，利用基因靶向技术来研究大脑的基本功能以及与精神和神经疾病相关的疾病。该中心通过其行政、动物测试设施和数据管理功能，将提供三个广泛的功能领域的行为评估：感觉运动、情感过程和认知，后者包括学习、记忆和注意力。 这些领域的表型分析将为申请中列出的 33 个研究人员/研究小组提供即时服务，这些研究小组位于马里兰州约翰霍普金斯大学和肯尼迪克里格研究所以及其他地点（麻省理工学院、布朗大学和田纳西州小鼠基因组联盟等）。 除了提供标准行为测试和数据分析设施外，该中心的研究人员都是国际公认的行为神经科学家，他们将合作开发适合用户研究目标的创新评估。 这些合作不仅将提高 NIH 资助的研究项目当前投资的质量，而且将通过传播该中心的活动为神经遗传学领域做出重大贡献。 该中心还将提供资源，培训年轻科学家掌握完成动物模型综合研究所需的广泛专业知识，从基因组、分子和细胞水平的分析到行为系统和功能障碍的研究。

DESCRIPTION (provided by applicant): The Neurogenetics and Behavior Center, supported under this award, would establish a unique resource for NIH supported research programs using gene targeting technology to study basic functions of the brain and disorders relevant to psychiatric and neurological disease. The Center, through its Administrative, Animal Testing Facility, and Data Management functions will provide behavioral assessments in three broad functional domains: sensorimotor, affective processes, and cognition, the latter to include learning, memory, and attention. Phenotypic analysis in these domains will provide an immediate service to 33 investigators/research groups listed in the application, located in Maryland at JHU and the Kennedy Krieger Institute and at other sites (Massachusetts Institute of Technology, Brown University, and the Tennessee Mouse Genome Consortium, among others). In addition to providing a facility for standard behavioral testing and data analysis, investigators in the Center, who are internationally recognized behavioral neuroscientists, will work collaboratively to develop innovative assessments appropriate to the research goals of the users. These collaborations will not only enhance the quality of current investments in research programs funded by the NIH but will make a significant contribution to the field of neurogenetics through dissemination of the Center's activities. The Center will also provide a resource for training young scientists in the wide range of expertise needed to accomplish integrative research with animal models, bridging from genomic, molecular, and cellular levels of analysis to the study of behavioral systems and functional disorders.