NEUROGENETICS AND BEHAVIOR CENTER

神经遗传学和行为中心

• 批准号: 7270023
• 负责人: Michela Gallagher
• 金额: $ 112.76万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7270023
• 关键词: Address; Affect; Affective; Animal Model; Animal Testing; Animals; Arts; Attention; Award; Behavior; Behavior assessment; Behavioral; Brain; Brain Diseases; Clinical; Cognition; Collaborations; Condition; Control Groups; Data Analyses; Emotional; Environment; Functional disorder; Funding; Gene Targeting; Genes; Genetic; Genomics; Goals; Institutes; Investments; Laboratories; Learning; Link; Maryland; Massachusetts; Memory; Mental disorders; Methods; Modification; Molecular; Molecular Genetics; Mus; N.I.H. Research Support; Neurophysiology - biologic function; Organ; Phenotype; Process; Protocols documentation; Range; Research; Research Personnel; Resources; Scientist; Screening procedure; Services; Site; Standards of Weights and Measures; System; Technology; Technology Transfer; Tennessee; Testing; Training; United States National Institutes of Health; Universities; Work; behavior test; data acquisition; data management; design; gene function; innovation; mouse genome; nervous system disorder; neurogenetics; programs; research study; sensorimotor system

DESCRIPTION (provided by applicant): The Neurogenetics and Behavior Center, supported under this award, would establish a unique resource for NIH supported research programs using gene targeting technology to study basic functions of the brain and disorders relevant to psychiatric and neurological disease. The Center, through its Administrative, Animal Testing Facility, and Data Management functions will provide behavioral assessments in three broad functional domains: sensorimotor, affective processes, and cognition, the latter to include learning, memory, and attention. Phenotypic analysis in these domains will provide an immediate service to 33 investigators/research groups listed in the application, located in Maryland at JHU and the Kennedy Krieger Institute and at other sites (Massachusetts Institute of Technology, Brown University, and the Tennessee Mouse Genome Consortium, among others). In addition to providing a facility for standard behavioral testing and data analysis, investigators in the Center, who are internationally recognized behavioral neuroscientists, will work collaboratively to develop innovative assessments appropriate to the research goals of the users. These collaborations will not only enhance the quality of current investments in research programs funded by the NIH but will make a significant contribution to the field of neurogenetics through dissemination of the Center's activities. The Center will also provide a resource for training young scientists in the wide range of expertise needed to accomplish integrative research with animal models, bridging from genomic, molecular, and cellular levels of analysis to the study of behavioral systems and functional disorders.

描述（由申请人提供）： 在该奖项的支持下，神经遗传学和行为中心将为NIH支持的研究项目建立一个独特的资源，该项目使用基因靶向技术研究大脑的基本功能以及与精神和神经疾病相关的疾病。该中心通过其行政、动物试验设施和数据管理职能，将在三个广泛的功能领域提供行为评估：感觉运动、情感过程和认知，后者包括学习、记忆和注意力。 这些领域的表型分析将为申请中列出的位于马里兰州JHU和肯尼迪克里格研究所以及其他研究中心（马萨诸塞州理工学院、布朗大学和田纳西小鼠基因组联盟等）的33个研究者/研究小组提供即时服务。 除了提供标准行为测试和数据分析的设施外，该中心的研究人员是国际公认的行为神经科学家，他们将合作开发适合用户研究目标的创新评估。 这些合作不仅将提高NIH资助的研究项目的当前投资的质量，而且将通过传播该中心的活动对神经遗传学领域做出重大贡献。 该中心还将提供一个资源，用于培训年轻科学家，掌握完成动物模型综合研究所需的广泛专业知识，从基因组，分子和细胞水平的分析到行为系统和功能障碍的研究。

项目成果

An assessment of olfaction and responses to novelty in three strains of mice.

对三种小鼠品系的嗅觉和对新奇事物的反应进行评估。

• DOI: 10.1016/j.bbr.2009.01.024
• 发表时间: 2009
• 期刊: Behavioural brain research
• 影响因子: 2.7
• 作者: Smith,DaniR;Burruss,DanielR;Johnson,AlexanderW
• 通讯作者: Johnson,AlexanderW

Functional integration of new neurons into hippocampal networks and poststroke comorbidities following neonatal stroke in mice.

• DOI: 10.1016/j.yebeh.2010.05.006
• 发表时间: 2010-08
• 期刊: Epilepsy & behavior : E&B
• 作者: Kadam SD;Smith-Hicks CL;Smith DR;Worley PF;Comi AM
• 通讯作者: Comi AM

Learning strategy selection in the water maze and hippocampal CREB phosphorylation differ in two inbred strains of mice.

两种近交系小鼠的水迷宫学习策略选择和海马 CREB ​​磷酸化有所不同。

• DOI: 10.1101/lm.783108
• 发表时间: 2008
• 期刊: Learning & memory (Cold Spring Harbor, N.Y.)
• 作者: Sung,Jin-Young;Goo,June-Seo;Lee,Dong-Eun;Jin,Da-Qing;Bizon,JenniferL;Gallagher,Michela;Han,Jung-Soo
• 通讯作者: Han,Jung-Soo