CORE VISION RESEARCH GRANT

描述（申请人提供）：犹他大学的视觉研究有超过17名教职员工和50多名支持人员，研究生和博士后。这项视觉研究核心基金的提案将加强12名参与研究人员的项目，他们总共获得了国家眼科研究所的15项R01奖。核心由(1)成像、(2)功能评估和(3)分子生物学模块组成，为参与研究者的项目提供全面的资源、培训和技术援助。此外，一个新颖的客户端-服务器应用程序（iLab）将为所有模块提供安全、统一的工作流和数据管理，促进访问、冲突解决、作业调度和数据跟踪。该工具确保了数据的完整性，并且任何数据集都可以被协作访问。成像模块将提供：(1)具有高速图像捕获的高分辨率光学成像；(2)激光共聚焦扫描显微镜（LSCM）；(3)高分辨率数字捕获电子显微镜（EM）；(4)光学、LSCM和EM数据的计算融合；(5)超低温切片服务，包括免疫细胞化学；(6)培训;(7)资源维护；(8)全面的数据存档。

DESCRIPTION (provided by applicant): Vision research at the University of Utah engages over 17 faculty members and 50+ supporting staff, graduate students and postdoctoral fellows. This proposal for a Vision Research Core Grant will enhance the programs of twelve participating investigators who collectively hold fifteen R01 awards from the National Eye Institute. The Core consists of (1) Imaging, (2) Functional Assessment, and (3) Molecular Biology modules, providing comprehensive resources, training and technical assistance to the programs of the participating investigators. In addition, a novel client-server application (iLab) will provide secure, uniform workflow and data management for all modules, facilitating access, conflict resolution, job scheduling and data tracking. This tool assures data integrity and any dataset can be collaboratively accessed. The Imaging Module will provide: (1) high-resolution optical imaging with high-speed image capture; (2) laser confocal scanning microscopy (LSCM); (3) electron microscopy (EM) with high-resolution digital capture; (4) computational fusion of optical, LSCM, and EM data; (5) ultramicrotomy cryomicrotomy services, including immunocytochemistry; (6) training; (7) resource maintenance; and (8) comprehensive data archiving. The Functional Assessment Module will provide: (1) comprehensive ERG/VEP visual testing; (2) optomotor behavioral tracking; (3) optical imaging of intrinsic CMS signals; (4) optical system calibration; (5) training; (6) resource maintenance; and (8) comprehensive data archiving. The Molecular Biology Module will provide: (1) high-capacity gene sequencing (2) robotics for sample processing; (3) IR imaging of blots and gels; (4) high-capacity ISH screening (5) training; (6) resource maintenance; and (7) comprehensive data archiving. Access to new technologies, training and technical support will facilitate collaborations, allow participating investigators to explore new research avenues and funding opportunities, and enhance the educational experience of graduate students, medical students, interns, residents and postdoctoral fellows.