CORE VISION RESEARCH GRANT

核心愿景研究补助金

• 批准号: 6941090
• 负责人: ROBERT E MARC
• 金额: $ 64.09万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941090
• 关键词: biomedical facility; imaging /visualization /scanning; vision

DESCRIPTION (provided by applicant): Vision research at the University of Utah engages over 17 faculty members and 50+ supporting staff, graduate students and postdoctoral fellows. This proposal for a Vision Research Core Grant will enhance the programs of twelve participating investigators who collectively hold fifteen R01 awards from the National Eye Institute. The Core consists of (1) Imaging, (2) Functional Assessment, and (3) Molecular Biology modules, providing comprehensive resources, training and technical assistance to the programs of the participating investigators. In addition, a novel client-server application (iLab) will provide secure, uniform workflow and data management for all modules, facilitating access, conflict resolution, job scheduling and data tracking. This tool assures data integrity and any dataset can be collaboratively accessed. The Imaging Module will provide: (1) high-resolution optical imaging with high-speed image capture; (2) laser confocal scanning microscopy (LSCM); (3) electron microscopy (EM) with high-resolution digital capture; (4) computational fusion of optical, LSCM, and EM data; (5) ultramicrotomy cryomicrotomy services, including immunocytochemistry; (6) training; (7) resource maintenance; and (8) comprehensive data archiving. The Functional Assessment Module will provide: (1) comprehensive ERG/VEP visual testing; (2) optomotor behavioral tracking; (3) optical imaging of intrinsic CMS signals; (4) optical system calibration; (5) training; (6) resource maintenance; and (8) comprehensive data archiving. The Molecular Biology Module will provide: (1) high-capacity gene sequencing (2) robotics for sample processing; (3) IR imaging of blots and gels; (4) high-capacity ISH screening (5) training; (6) resource maintenance; and (7) comprehensive data archiving. Access to new technologies, training and technical support will facilitate collaborations, allow participating investigators to explore new research avenues and funding opportunities, and enhance the educational experience of graduate students, medical students, interns, residents and postdoctoral fellows.

描述(由申请者提供)：犹他大学视觉研究拥有17名教职员工和50多名辅助人员、研究生和博士后研究员。这项关于视力研究核心拨款的提案将加强12名参与研究的研究人员的计划，他们总共拥有国家眼科研究所颁发的15个R01奖。核心包括(1)成像，(2)功能评估，和(3)分子生物学模块，为参与研究人员的项目提供全面的资源、培训和技术援助。此外，一个新的客户-服务器应用程序(ILab)将为所有模块提供安全、统一的工作流程和数据管理，促进访问、冲突解决、作业调度和数据跟踪。此工具可确保数据完整性，并且可以协作访问任何数据集。成像模块将提供：(1)具有高速图像捕获的高分辨率光学成像；(2)激光共聚焦扫描显微镜(LSCM)；(3)具有高分辨率数字捕获的电子显微镜(EM)；(4)光学、LSCM和EM数据的计算融合；(5)超微切割冷冻显微切割服务，包括免疫细胞化学；(6)培训；(7)资源维护；以及(8)全面的数据归档。 功能评估模块将提供：(1)全面的ERG/VEP视觉测试；(2)视觉运动行为跟踪；(3)固有CMS信号的光学成像；(4)光学系统校准；(5)培训；(6)资源维护；(8)全面的数据存档。 分子生物学模块将提供：(1)高容量基因测序(2)用于样品处理的机器人；(3)斑点和凝胶的红外成像；(4)高容量ISH筛查；(5)培训；(6)资源维护；以及(7)全面的数据存档。获得新技术、培训和技术支持将促进合作，使参与的调查人员能够探索新的研究途径和筹资机会，并加强研究生、医学生、实习生、住院医生和博士后研究员的教育经验。