Decarboxylative fluorination and trifluoromethylation of benzoic acids

苯甲酸的脱羧氟化和三氟甲基化

• 批准号: 2481226
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2481226
• 关键词: Decarboxylative; fluorination; trifluoromethylation; benzoic; acids

Objective:This project will investigate the development of novel catalytic methods capable of transforming benzoic acids and heteroaromatic carboxylic acids into the corresponding decarboxofluorinated products. Approach:The student will examine the use of transition metal catalysts to mediate the 'activation' of the carboxyl C-C bond, resulting in a decarboxylative process. Subsequently, this process shall be coupled with a C-F bond forming step. Novelty:There are no broad methods available to carry out this transformation. Benzoic acids are extremely readily available, and fluorinated motifs are common in drugs and other biologically active molecules.

目的：本项目将研究新型催化方法，能够将苯甲酸和杂芳羧酸转化为相应的脱羧氟产物。方法：学生将研究使用过渡金属催化剂来介导羧基C-C键的“活化”，从而导致脱羧过程。随后，该过程应与C-F键合形成步骤相结合。新奇：没有广泛的方法可以进行这种转换。苯甲酸非常容易获得，并且氟化基序在药物和其他生物活性分子中很常见。