Fluorination with simple fluorides in water

水中简单氟化物的氟化

• 批准号: 2882600
• 金额: --
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2882600
• 关键词: Fluorination; simple; fluorides; water

Fluorination with simple fluoride salts in water is a highly sustainable approach to manufacturing of fluorine-containing APIs. Research in Nguyen group have shown that surfactants, whose selection is guided by a surfactant_map, can enable these processes by fine tuning the degree of hydration of the fluoride anion and its reactivity. In this project, we will further develop these ground-breaking findings into potential manufacturing processes by delivering: (i) a wider substrate pool; (ii) purification protocols to avoid contamination with surfactants; and (iii) continuous processes which include surfactant/fluoride recycling for true sustainability.

在水中用简单的氟化物盐进行氟化是生产含氟原料药的一种高度可持续的方法。Nguyen小组的研究表明，表面活性剂的选择由表面活性剂图谱指导，可以通过微调氟阴离子的水合程度及其反应性来实现这些过程。在这个项目中，我们将进一步开发这些突破性的发现，通过提供潜在的制造工艺：（i）更广泛的底物池;（ii）纯化协议，以避免表面活性剂的污染;和（iii）连续的过程，包括表面活性剂/氟化物回收真正的可持续性。