A randomized clinical trial comparing effectiveness of 4RIF and 9INH for treatment of latent TB infection

一项比较 4RIF 和 9INH 治疗潜伏性结核感染有效性的随机临床试验

• 批准号: nhmrc : 632857
• 负责人: Prof Guy Marks
• 金额: $ 33.13万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/randomized-clinical-trial-tb-infection/83097
• 关键词: randomized; clinical; trial; comparing; effectiveness

Treatment of latent tuberculosis infection (LTBI) is one intervention that is known to prevent the occurrence of active TB. Current treatment is based on a six to nine month course of isoniazid. The treatment has side effects in some people and many people do not complete the treatment. The present study is to test an alternative treatment regimen (4 months of rifampicin) which has fewer side-effects and is more likely to be completed.

潜伏性结核感染（LTBI）的治疗是一种已知的预防活动性结核病发生的干预措施。目前的治疗是基于6至9个月的异烟肼疗程。治疗对某些人有副作用，许多人没有完成治疗。目前的研究是测试一种替代治疗方案（4个月的利福平），副作用较少，更有可能完成。