Development of Semi-Artificial Pancreas using Natural Polymers

使用天然聚合物开发半人工胰腺

• 批准号: 2485443
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2485443
• 关键词: Development; Semi; Artificial; Pancreas; using

Type 1 diabetes is an organ-specific autoimmune disease in which the immune system attacks the insulin-producing beta-cells, resulting in the loss of these cells, hence leading to insulin deficiency. It affects over 16 million people worldwide. Diabetes can lead to stroke, kidney failure, blindness, cardiovascular and nerve disease, diabetic coma, and premature mortality.Polyhydroxyalkanoates (PHAs) are naturally occurring polyesters which are versatile biomaterials due to their ease of chemical functionalisation, bioresorbability and biocompatibility. In this project we will aim to create a semiartificial pancreas which will constitute two main components, an outer protective layer created using PHAs in their thermoplastic form and an inner compartment containing insulin producing Islets of Langerhans microencapsulated within PHA based hydrogels. The pancreatic structure will be mimicked to create a similar multi-compartment construct. Hence, overall this project will involve the development of a Bioartificial Pancreas using PHA based thermoplastics and hydrogels leading to a highly biocompatible insulin releasing medical device for the effective treatment of Type 1 diabetes.

1型糖尿病是一种器官特异性自身免疫性疾病，免疫系统攻击产生胰岛素的β细胞，导致这些细胞丢失，从而导致胰岛素缺乏。它影响着全球1600多万人。糖尿病可导致中风、肾功能衰竭、失明、心血管和神经疾病、糖尿病昏迷和过早死亡。聚羟基烷酸酯(PHAs)是一种天然存在的聚酯，由于其易于化学功能化、生物可吸收和生物兼容性，是一种用途广泛的生物材料。在这个项目中，我们的目标是创建一个半人工胰腺，它将由两个主要组件组成，一个是使用热塑性PHAs创建的外部保护层，另一个是包含以PHA为基础的水凝胶内微胶囊的朗格汉斯胰岛素产生胰岛的内室。胰腺结构将被模仿，以创建类似的多间隔结构。因此，总体来说，该项目将涉及使用基于PHA的热塑性塑料和水凝胶的生物人工胰腺的开发，从而导致用于有效治疗1型糖尿病的高度生物兼容的胰岛素释放医疗设备。