Comorbid childhood anxiety and asthma

描述（由研究者提供）：申请人要求5年 通过指导的以患者为导向的研究职业发展的资金 奖（K23）计划，以提高她的技术和方法技能， 焦虑症与哮喘/变态反应共病的调查 青年最终的目标是获得专业知识之间的关系， 焦虑症和哮喘/过敏症的共同发生以及严重 青年精神病理学，采用纵向流行病学研究 方法，并最终确定预防措施。的 申请人在人类发展，临床， 心理学和精神病学，以及她的研究经验， 发展范式研究严重精神病理学的风险， 患有早发性焦虑症的人提供了良好的基础， 为了这项工作。拟议的培训目标包括：（1）进一步培训， 增加申请人对呼吸系统疾病之间关系的认识 病理生理学和焦虑症;（2）高级统计培训和 具有纵向数据分析和调查方法的经验;（3） 整合焦虑研究的潜在干预措施的调查 疾病和哮喘/过敏。这些目标都将有助于申请人的 采用创新、全面和技术上有效的办法， 研究这些年轻人的合并症。该奖项的研究计划存在分歧 四项调查，补充拟议的培训顺序 活动，并为申请人提供机会，探索重要的 来自流行病学、临床和社区的横断面和纵向数据 样品，以及动手经验，在前两项研究中， 申请人将分析先前收集的数据（MECA & SED和达尼丁）。在 在第三项研究中，申请人将前瞻性收集自己的哮喘数据 （网络研究），在一个正在进行的纵向流行病学临床 （精神病学）调查，同时学习如何进行研究。第四 调查将涉及制定措施和收集试验数据， 哮喘和焦虑的临床（医学）样本。申请人的结果 R 01将解决上述发展范式，这将是 进一步测试，并将包括早期干预战略，以促进 查明和治疗有严重 精神病理学这项研究将涉及纵向流行病学 旨在降低焦虑症风险的预防性干预研究 儿童哮喘/过敏症患者中。

DESCRIPTION (provided by investigator): The applicant is requesting five years of funding through the Mentored Patient-Oriented Research Career Development Award (K23) program to enhance her technical and methodological skills in the investigation of the co-occurrence of anxiety disorders and asthma/allergy in youth. The ultimate goal is to gain expertise in the relationship between the co-occurrence of anxiety disorders and asthma/allergy and the risk of severe psychopathology among youth, using longitudinal, epidemiologic research methodology and ultimately to identify preventive interventions. The applicant's strong academic background in human development, clinical psychology, and psychiatric epidemiology, and her research experience using a developmental paradigm to study risk for severe psychopathology among individuals with early-onset anxiety disorders provide an excellent foundation for this work. The proposed training goals include (1) further training to increase the applicant's knowledge of the relationship between respiratory pathophysiology and anxiety disorders; (2) advanced statistical training and experience with longitudinal data analysis and survey methods, and; (3) investigation of potential interventions that integrate research on anxiety disorders and asthma/allergy. These goals will all facilitate the applicant's pursuit of innovative, comprehensive, technologically efficient approaches to study these comorbidities in youth. The research plan for this Award is divided into four investigations which complement the proposed sequence of training activities and offer the applicant the opportunity to explore important cross-sectional and longitudinal data from epidemiologic clinical and community samples, as well as hands-on experience, in the first two studies, the applicant will analyze previously collected data (MECA & SED and Dunedin). In the third study, the applicant will collect her own asthma data prospectively (Network study), in an ongoing longitudinal epidemiologic clinical (psychiatric) investigation, while learning how to conduct a study. The fourth investigation will involve developing measures and collecting pilot data on asthma and anxiety in a clinical (medical) sample. The applicant's resulting ROl will address the developmental paradigm described above, which will be further tested and will include early intervention strategies to facilitate the identification and treatment of children who are at risk for severe psychopathology. That study will involve a longitudinal epidemiologic preventive intervention study aimed at reducing the risk of anxiety disorders among pediatric asthma/allergy patients.