Genetic Models of Cardiovascular Renal & Pulmonary

心血管肾遗传模型

• 批准号: 6894855
• 负责人: MARIO R CAPECCHI
• 金额: $ 18.59万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6894855
• 关键词: Genetic; Models; Cardiovascular; Renal; Pulmonary

DESCRIPTION (provided by applicant): We propose the creation of a multidisciplinary Research Training Program that will integrate the expertise of leading clinical and fundamental research scientists at the University of Utah in the use of animal models to investigate genetic mechanisms underlying cardiovascular, renal and pulmonary diseases. We will offer post-doctoral training (clinical-scientists or Ph.D.), graduate training, and short-term training in the use of animals to investigate genes and pathways involved in disease, with the primary goals of improving diagnosis and identifying new drug targets for treatment of common cardiovascular, renal, and pulmonary diseases. Expertise must be developed not only in generating genetically altered animals but also in characterizing and analyzing their phenotypes. Trainees will be exposed to the broad range of emerging technologies in the fields of gene manipulation, quantitative genetics, functional genomics, biochemistry, physiology, imaging, behavior, bioinformatics and statistics required to carry out comprehensive research in the genetics of common disease. Thirty six faculty members from clinical and basic sciences departments will serve as preceptors for the trainees, drawn on one hand from the Clinical Divisions or Departments of Cardiology, Endocrinology, Hematology, Nephrology, Pulmonary Division, Pediatrics, and Medical Genetics, and on the other hand from the Basic Sciences Departments or Divisions of Human Genetics, Biochemistry, Medical Informatics, Genetic Epidemiology, Biomathematics, Computer Science and Mathematics. The didactic part of the Training Program at both the Post-Graduate and Graduate levels are already in place at the University. Dual mentoring of individual students by faculty from clinical and basic sciences departments, together with the breath of perspective developed in the curriculum and the research program, should provide trainees with a solid preparation to participate in the multidisciplinary research teams of future biomedical research. (END OF ABSTRACT)

描述（由申请人提供）：我们提议建立一个多学科研究培训计划，该计划将整合犹他大学领先的临床和基础研究科学家的专业知识，利用动物模型研究心血管、肾脏和肺部疾病的遗传机制。我们将提供博士后培训（临床科学家或博士），研究生培训，以及利用动物研究疾病基因和途径的短期培训，主要目标是提高诊断和确定治疗常见心血管，肾脏和肺部疾病的新药靶点。专业知识不仅要在产生转基因动物方面得到发展，而且要在表征和分析它们的表型方面得到发展。学员将接触到基因操作、数量遗传学、功能基因组学、生物化学、生理学、影像学、行为学、生物信息学和统计学等领域的广泛新兴技术，以开展常见疾病遗传学的综合研究。来自临床和基础科学院系的36名教师将担任培训生的导师，他们一方面来自临床院系或心脏科、内分泌科、血液科、肾脏病科、肺科、儿科和医学遗传学院系，另一方面来自基础科学院系或人类遗传学、生物化学、医学信息学、遗传流行病学、生物数学、计算机科学和数学院系。研究生和研究生水平的培训计划的教学部分已经在大学到位。临床和基础科学院系教师对个别学生的双重指导，加上课程和研究计划中发展的观点，应该为学员参与未来生物医学研究的多学科研究团队提供坚实的准备。（摘要结束）