Training in Lung Modular and Cell Pathobiology

描述（由申请人提供）： 杜兰大学在肺部疾病的生物医学和基础分子研究方面建立了坚实的基础。1992年，作为杜兰大学校园战略计划的一部分，为了改善和现代化肺部研究活动，进入细胞和分子病理生物学领域，Mitchell Friedman博士（首席研究员）和Arnold Brody博士（共同首席研究员）被招募到杜兰大学医学中心。弗里德曼博士是杜兰大学医学中心的医学教授和肺病、重症监护和环境医学科科长。布罗迪博士目前是病理学教授，杜兰病理学系副主任和杜兰肺生物学项目主任。随着弗里德曼和布罗迪博士的招募，一个坚实的和高度竞争的肺部疾病研究计划已经发展成为杜兰大学在过去七年中高度合作的肺部生物学计划。肺生物学项目的个别教员代表医学院的两个部门（医学，病理学和所有研究奖励给这些研究人员的总额约为300万美元/年。此外，关键的互动研究计划已经在杜兰大学Ltmg生物学计划和杜兰大学的其他研究中心，包括基因治疗中心，生物医学工程系，药理学系和杜兰癌症中心之间开发。每年授予全体教员的联邦和非联邦资金总额现在约为1020万美元的直接费用。该研究奖级别包括NIH，DoD，NIOSH，LA州，协会和基金会的赠款。作为教师生产力的一个例子，1998-2002年，在著名期刊上发表了大约113篇文章，并在国家和国际会议上发表了许多演讲。主要研究领域为肺纤维化、肺癌、肺循环、哮喘、慢性阻塞性肺病、基因治疗、吸入性毒物对肺和气道炎症机制的影响。自1992年以来，杜兰大学肺细胞和分子病理学研究人员和研究项目的快速增长也与博士前和博士后培训活动的发展有关。目前有23名受训人员接受培训学院的指导。这些学员的资金目前来自个别教师的研究赠款和合同，从杜兰分子和细胞生物学计划和杜兰/泽维尔生物环境研究中心，基金会和捐赠基金的资金。肺、重症监护和环境医学科还为9名临床研究员提供肺和重症监护医学培训。培训方案的多样性体现在以下事实上：在这些受训人员中，有9名女性、3名黑人、1名美洲土著人和7名亚洲人。该培训项目的师资队伍，自1992年以来，已有64名博士后学员获得学术教职。在肺部疾病的细胞和分子水平上的广泛研究活动，教师的成就和培训的跟踪记录，为我们的学员提供优秀的研究经验，教师和学员的生产力，如他们的出版记录和赠款资金证明，以及事实上，一些学员已获得教师职位作为提交这一新的T-32项培训补助金，用于提供肺细胞和分子病理学方面的正式研究培训。本项目的主要目标是培养高素质的博士后研究生，主要研究肺部疾病的基本机制，重点是肺部细胞和分子生物学。该计划的学员利用新兴技术和新方法，将获得设计和进行病理生物学基础研究的必要技能。我们已经制定了一个正式的2年培训计划（指导实验室研究项目和正式的核心课程），以准备学员在肺生物学研究中发展成功和独立的学术生涯。

DESCRIPTION (provided by applicant): A solid base of biomedical and basic molecular research in lung diseases has evolved at Tulane University. In 1992, as part of a campus wide strategic plan by Tulane to improve and modernize the lung research activities into the areas of cell and molecular pathobiology Drs. Mitchell Friedman (Principal Investigator) and Arnold Brody (Co-Principal Investigator) were recruited to Tulane University Medical Center. Dr. Friedman is Professor of Medicine and Chief of the Section of Pulmonary Diseases, Critical Care and Environmental Medicine at Tulane University Medical Center. Dr. Brody is currently Professor of Pathology, Vice Chairman of the Department of Pathology at Tulane and Director of the Tulane Lung Biology Program. With the recruitment of Drs. Friedman and Brody a solid and highly competitive lung disease research program has evolved into the highly collaborative Lung Biology Program at Tulane University over the past seven years. The individual faculty members of the Lung Biology Program represent two departments in the Medical School (Medicine, Pathology and the total amount of all research awards to these investigators is approximately $3 million/year. Furthermore, critical interactive research programs have been developed between the Tulane Ltmg Biology Program and other research centers at Tulane including the Center for Gene Therapy, Department of Biomedical Engineering, Department of Pharmacology, and the Tulane Cancer Center. The total federal and non-federal monies awarded to the entire faculty on a yearly basis is now approximately $10,200,000 in direct costs. This research award level includes grants from the NIH, DoD, NIOSH, State of LA, associations, and foundations. As an example of productivity of the faculty, for 1998-2002, there have been approximately 113 publications in prestigious journals and numerous presentations at national and international meetings. The main research areas are in mechanisms of lung fibrosis, lung cancer, pulmonary circulation, asthma, COPD, gene therapy, and effects of inhaled toxicants on the lung and airway inflammation mechanisms. The rapid growth of research faculty and research projects in lung ceil and molecular pathobiology at Tulane since 1992 has also been associated with the development of pre-doctoral and post-doctoral training activities. There are presently 23 trainees being mentored by the training faculty. The funding for these trainees are presently derived from individual faculty research grants and contracts, funding from the Tulane Molecular and Cell Biology Program and the Tulane/Xavier Center for Bioenvironmental Research, and foundations and endowments. The Pulmonary, Critical Care and Environmental Medicine Section also provides training for 9 clinical fellows in Pulmonary and Critical Care Medicine. The diversity of the training program is exemplified by the fact that of these trainees, 9 were female, 3 Black, 1 Native American and 7 Asian. The Training program faculty, since 1992, have had 64 post-doctoral trainees obtain academic faculty positions. The wide range of research activities at the cell and molecular level in lung disease, the track record of achievement and training by the faculty, the development of excellent research experience for our trainees, the productivity of the faculty and trainees as evidenced by their publication record and grant funding and the fact that a number of trainees have obtained faculty positions serve as the basis for the submission of this new T-32 training grant to offer funded formalized research training in lung cell and molecular pathobiology. The main objective of this proposal is to train highly-qualified post-doctoral students in basic mechanisms of lung disease focusing on lung cell and molecular biology. Trainees in the Program, utilizing emerging technologies and new approaches, will acquire the necessary skills to design and conduct basic research studies in pathobiology. We have developed a formalized 2-year training program (a mentored laboratory research project and a formalized core curriculum) to prepare the trainees to develop a successful and independent academic career in research in lung biology.