Training in Lung Modular and Cell Pathobiology

描述(由申请人提供)： 杜兰大学为肺部疾病的生物医学和基础分子研究奠定了坚实的基础。1992年，作为杜兰大学将肺部研究活动改进和现代化到细胞和分子病理生物学领域的全校战略计划的一部分，米切尔·弗里德曼博士(首席研究员)和阿诺德·布罗迪博士(联合首席研究员)应聘到杜兰大学医学中心。弗里德曼博士是杜兰大学医学中心的医学教授和肺部疾病、重症监护和环境医学部主任。布罗迪博士目前是病理学教授、杜兰大学病理学系副主任和杜兰大学肺生物学项目主任。随着弗里德曼博士和布罗迪博士的招聘，在过去的七年里，一个坚实且具有高度竞争力的肺部疾病研究项目已经演变为杜兰大学高度合作的肺部生物学项目。肺生物学项目的个别教员代表医学院的两个系(医学、病理学和医学)，这些研究人员获得的所有研究奖励总额约为每年300万美元。此外，杜兰LTMG生物学计划和杜兰的其他研究中心，包括基因治疗中心、生物医学工程系、药理学系和杜兰癌症中心，已经开发了关键的互动研究计划。现在，每年发放给全体教职员工的联邦和非联邦资金总额约为1020万美元的直接成本。这一研究奖励级别包括来自NIH、国防部、NIOSH、洛杉矶州立大学、协会和基金会的拨款。作为教师生产力的一个例子，1998-2002年，在著名期刊上发表了大约113篇文章，并在国内和国际会议上发表了许多演讲。主要研究领域包括肺纤维化、肺癌、肺循环、哮喘、COPD、基因治疗以及吸入毒物对肺和呼吸道炎症机制的影响。自1992年以来，杜兰大学在肺细胞和分子病理生物学方面的研究人员和研究项目迅速增长，这也与博士后和博士后培训活动的开展有关。目前有23名学员正在接受培训部的指导。这些受训人员的资金目前来自教师个人研究补助金和合同，杜兰分子和细胞生物学计划和杜兰/泽维尔生物环境研究中心的资金，以及基金会和捐赠基金。肺、重症护理和环境医学科还为9名肺部和重症护理医学临床研究员提供培训。这些受训者中有9名女性、3名黑人、1名美洲原住民和7名亚洲人，这一事实证明了培训计划的多样性。师资培训项目自1992年起，先后有博士后学员取得教职。在肺部疾病方面广泛的细胞和分子水平的研究活动，教员取得成就和培训的记录，我们受训人员出色的研究经验的发展，他们的出版记录和拨款证明了教员和受训人员的生产力，以及一些受训人员已经获得教职的事实，这些都是提交这项新的T-32培训拨款的基础，以提供资助的肺细胞和分子病理生物学的正式研究培训。这项建议的主要目标是培养高素质的博士后，了解肺部疾病的基本机制，重点是肺细胞和分子生物学。该计划的受训人员将利用新兴技术和新方法，获得设计和进行病理生物学基础研究所需的技能。我们已经制定了一个正式的两年培训计划(一个有指导的实验室研究项目和一个正式的核心课程)，为学员在肺部生物学研究中发展成功和独立的学术生涯做好准备。

DESCRIPTION (provided by applicant): A solid base of biomedical and basic molecular research in lung diseases has evolved at Tulane University. In 1992, as part of a campus wide strategic plan by Tulane to improve and modernize the lung research activities into the areas of cell and molecular pathobiology Drs. Mitchell Friedman (Principal Investigator) and Arnold Brody (Co-Principal Investigator) were recruited to Tulane University Medical Center. Dr. Friedman is Professor of Medicine and Chief of the Section of Pulmonary Diseases, Critical Care and Environmental Medicine at Tulane University Medical Center. Dr. Brody is currently Professor of Pathology, Vice Chairman of the Department of Pathology at Tulane and Director of the Tulane Lung Biology Program. With the recruitment of Drs. Friedman and Brody a solid and highly competitive lung disease research program has evolved into the highly collaborative Lung Biology Program at Tulane University over the past seven years. The individual faculty members of the Lung Biology Program represent two departments in the Medical School (Medicine, Pathology and the total amount of all research awards to these investigators is approximately $3 million/year. Furthermore, critical interactive research programs have been developed between the Tulane Ltmg Biology Program and other research centers at Tulane including the Center for Gene Therapy, Department of Biomedical Engineering, Department of Pharmacology, and the Tulane Cancer Center. The total federal and non-federal monies awarded to the entire faculty on a yearly basis is now approximately $10,200,000 in direct costs. This research award level includes grants from the NIH, DoD, NIOSH, State of LA, associations, and foundations. As an example of productivity of the faculty, for 1998-2002, there have been approximately 113 publications in prestigious journals and numerous presentations at national and international meetings. The main research areas are in mechanisms of lung fibrosis, lung cancer, pulmonary circulation, asthma, COPD, gene therapy, and effects of inhaled toxicants on the lung and airway inflammation mechanisms. The rapid growth of research faculty and research projects in lung ceil and molecular pathobiology at Tulane since 1992 has also been associated with the development of pre-doctoral and post-doctoral training activities. There are presently 23 trainees being mentored by the training faculty. The funding for these trainees are presently derived from individual faculty research grants and contracts, funding from the Tulane Molecular and Cell Biology Program and the Tulane/Xavier Center for Bioenvironmental Research, and foundations and endowments. The Pulmonary, Critical Care and Environmental Medicine Section also provides training for 9 clinical fellows in Pulmonary and Critical Care Medicine. The diversity of the training program is exemplified by the fact that of these trainees, 9 were female, 3 Black, 1 Native American and 7 Asian. The Training program faculty, since 1992, have had 64 post-doctoral trainees obtain academic faculty positions. The wide range of research activities at the cell and molecular level in lung disease, the track record of achievement and training by the faculty, the development of excellent research experience for our trainees, the productivity of the faculty and trainees as evidenced by their publication record and grant funding and the fact that a number of trainees have obtained faculty positions serve as the basis for the submission of this new T-32 training grant to offer funded formalized research training in lung cell and molecular pathobiology. The main objective of this proposal is to train highly-qualified post-doctoral students in basic mechanisms of lung disease focusing on lung cell and molecular biology. Trainees in the Program, utilizing emerging technologies and new approaches, will acquire the necessary skills to design and conduct basic research studies in pathobiology. We have developed a formalized 2-year training program (a mentored laboratory research project and a formalized core curriculum) to prepare the trainees to develop a successful and independent academic career in research in lung biology.