The effects of stressful life events and trauma on brain structure and subsequent development of psychopathology

压力生活事件和创伤对大脑结构的影响以及精神病理学的后续发展

• 批准号: 2487940
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2487940
• 关键词: effects; stressful; life; events; trauma

Stressful and traumatic events are recognised as important risk factors for a number of psychiatric disorders, however it hasbeen difficult to identify the mechanism of how stress leads to psychopathology (McEwen and Stellar, 1993). Previous work hasdemonstrated that stressful life events affect brain structure, notably observed as reduction in grey matter volume (GMV) withinregions such as the hippocampus, anterior cingulate cortex (ACC) and orbitofrontal cortex. It is theorised that an over-exposureto stress hormones such as glucocorticoids results in dendritic atrophy, reduced neurogenesis, and neuronal death, resulting inan observable reduction in GMV (Radley and Morrison, 2005).

应激和创伤事件被认为是许多精神障碍的重要风险因素，然而，很难确定压力如何导致精神病理的机制(McEwen和Stella，1993)。先前的研究表明，应激性生活事件会影响大脑结构，尤其是在海马区、前扣带回皮质(ACC)和眼眶额叶皮质等区域观察到灰质体积(GMV)的减少。理论上，过度暴露于糖皮质激素等应激激素会导致树突萎缩、神经发生减少和神经元死亡，从而导致GMV明显减少(Radley和Morison，2005)。