TRAINING GRANT IN HEMOSTASIS AND THROMBOSIS

在过去的几年中，在止血和血栓形成领域中已经有了令人兴奋的进展。 在理解疾病的分子基础、建立这些疾病的动物模型及其治疗方面取得了迅速进展。 宾夕法尼亚大学的研究人员在这些领域做出了重要贡献。 在这些领域，我们有一个庞大的和不断增长的互动研究机构，但没有培训补助金，以支持止血和血栓形成的博士前和博士后研究员的培训。 目前，在我们的校园里有三个大型项目和一个止血和血栓形成领域的SCOR。然而，没有有组织的计划来培训这些领域的博士前和博士后研究员。 我们相信，止血和血栓形成研究在我们的校园进一步增长需要这样的培训结构。 受训人员可能感兴趣的具体领域包括各种凝血因子的结构/功能;血友病患者的基因治疗;体外和小鼠模型中的血小板生物学;血管系统的发育和病理生物学;以及这些临床疾病如血栓形成倾向和肝素化的分子基础，诱导性血小板减少症这一拟议的培训补助金将具有几个关键特征，这将使其成为培训未来研究者止血和血栓形成的有效机制。 第一个组成部分是一个组织良好的监督委员会，它将确保优秀的实习生候选人不仅在他们的研究中取得成功，而且在止血和血栓形成领域获得全面培训。 第二部分是设计一个必要的教学系列讲座，以提供博士学位。学员对止血和血栓形成的临床方面有全面的了解，并提供医学博士培训生全面接触这些领域的各种基础科学问题和方法。 另一个必修课程是由国家和国际公认的研究人员提供的心血管研讨会系列。学员将有一个独特的机会，不仅听取他们的研究研讨会，但讨论的研究工作，这些研究人员在一个特别会议的学员与研究人员。 第三个组成部分是半年一次的评估表，这将使监督委员会能够在受训人员在研究工作或课程工作中遇到问题时及早进行干预。 (End摘要）

DESCRIPTION (Applicant's Abstract) There have been exciting advances in the areas of hemostasis and thrombosis in the past several years. Rapid advances have occurred in the understanding of the molecular basis of diseases, establishment of animal models for these disorders and in their treatment. Investigators at the University of Pennsylvania have made important contributions to these areas. We have a large and growing body of interactive investigators in these fields, but no training grant to support the training of pre- and post-doctoral fellows in hemostasis and thrombosis. At the moment, there are three large Program Projects and one SCOR in the areas of hemostasis and thrombosis on our campus. Yet, there is no organized program for training pre- and post-doctoral fellows in these areas. We believe that the further growth of research in hemostasis and thrombosis on our campus requires such a training structure. Specific areas of interest that trainees might pursue include structure/function of various coagulation factors; gene therapy for the hemophiliacs; platelet biology both in vitro and in murine models; the development and pathobiology of the vascular system; and the molecular basis of such clinical disorders such as thrombophilia and Heparin-Induced Thrombocytopenia This proposed training grant will have several key features that will make it a productive mechanism for training future investigators in hemostasis and thrombosis. The first component is a well-organized Oversight Committee that will ensure that outstanding trainee candidates are not only successful in their research, but in the obtainment of overall training in the fields of hemostasis and thrombosis. The secondcomponent is the design of a required didactic lecture series to provide the Ph.D. trainee with a well-rounded understanding of the clinical aspects of hemostasis and thrombosis and to provide the M.D. trainee with a well-rounded exposure to the various basic science issues and approaches in these fields. Another required course is the Cardiovascular Seminar Series given by national and internationally recognized investigators. The trainees will be provided with a unique opportunity to not only hear their research seminars, but to discuss the research effort by these investigators in a special session of trainees with investigator. The third component is a semi- annual evaluation form that will allow the Oversight Committee to intervene early when a trainee is having problems in either their research effort or course work. (End of Abstract)