TRAINING GRANT IN HEMOSTASIS AND THROMBOSIS

止血和血栓形成培训补助金

• 批准号: 6896213
• 负责人: Douglas Brock Cines
• 金额: $ 47.01万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6896213
• 关键词: TRAINING; GRANT; HEMOSTASIS; THROMBOSIS

DESCRIPTION (Applicant's Abstract) There have been exciting advances in the areas of hemostasis and thrombosis in the past several years. Rapid advances have occurred in the understanding of the molecular basis of diseases, establishment of animal models for these disorders and in their treatment. Investigators at the University of Pennsylvania have made important contributions to these areas. We have a large and growing body of interactive investigators in these fields, but no training grant to support the training of pre- and post-doctoral fellows in hemostasis and thrombosis. At the moment, there are three large Program Projects and one SCOR in the areas of hemostasis and thrombosis on our campus. Yet, there is no organized program for training pre- and post-doctoral fellows in these areas. We believe that the further growth of research in hemostasis and thrombosis on our campus requires such a training structure. Specific areas of interest that trainees might pursue include structure/function of various coagulation factors; gene therapy for the hemophiliacs; platelet biology both in vitro and in murine models; the development and pathobiology of the vascular system; and the molecular basis of such clinical disorders such as thrombophilia and Heparin-Induced Thrombocytopenia This proposed training grant will have several key features that will make it a productive mechanism for training future investigators in hemostasis and thrombosis. The first component is a well-organized Oversight Committee that will ensure that outstanding trainee candidates are not only successful in their research, but in the obtainment of overall training in the fields of hemostasis and thrombosis. The secondcomponent is the design of a required didactic lecture series to provide the Ph.D. trainee with a well-rounded understanding of the clinical aspects of hemostasis and thrombosis and to provide the M.D. trainee with a well-rounded exposure to the various basic science issues and approaches in these fields. Another required course is the Cardiovascular Seminar Series given by national and internationally recognized investigators. The trainees will be provided with a unique opportunity to not only hear their research seminars, but to discuss the research effort by these investigators in a special session of trainees with investigator. The third component is a semi- annual evaluation form that will allow the Oversight Committee to intervene early when a trainee is having problems in either their research effort or course work. (End of Abstract)

描述(申请人摘要)在过去的几年中，止血和血栓形成领域取得了令人兴奋的进展。在理解疾病的分子基础、建立这些疾病的动物模型及其治疗方面取得了快速进展。宾夕法尼亚大学的研究人员在这些领域做出了重要贡献。我们在这些领域有大量且不断增长的互动研究人员，但没有培训补助金来支持博士后和博士后研究员在止血和血栓形成方面的培训。目前，我校在止血和血栓形成领域有三个大型项目和一个SCOR项目。然而，在这些领域，没有培训博士后和博士后研究员的有组织的计划。我们认为，我们校园止血和血栓形成研究的进一步增长需要这样的培训结构。学员感兴趣的具体领域包括各种凝血因子的结构/功能；血友病患者的基因治疗；体外和小鼠模型中的血小板生物学；血管系统的发展和病理生物学；以及此类临床疾病的分子基础，如血栓形成症和肝素诱导的血小板减少症。这项拟议的培训基金将具有几个关键特征，使其成为培训未来研究人员止血和血栓形成的有效机制。第一个组成部分是一个组织严密的监督委员会，它将确保优秀的受训候选人不仅在研究方面取得成功，而且在止血和血栓形成领域获得全面培训。第二个部分是设计必要的教学讲座系列，为博士生提供止血和血栓形成的临床方面的全面了解，并为医学博士实习生提供全面接触这些领域的各种基础科学问题和方法。另一门必修课是由国家和国际公认的研究人员讲授的心血管研讨会系列。受训者将获得一个独特的机会，不仅可以听取他们的研究研讨会，还可以在受训者与调查员的特别会议上讨论这些调查人员的研究努力。第三部分是半年度评估表，当受训者在研究工作或课程工作中遇到问题时，监督委员会可以及早进行干预。(摘要结束)