Training Grant in Hemostasis and Thrombosis

在过去的几年里，止血和血栓形成领域取得了令人兴奋的进展。在了解疾病的分子基础、建立这些疾病的动物模型及其治疗方面取得了迅速进展。宾夕法尼亚大学的研究人员在这些领域做出了重要贡献。我们在这些领域有一个庞大且不断增长的互动研究机构，但没有培训经费来支持止血和血栓形成方面的博士后和博士后研究员的培训。目前，我校在止血和血栓领域有3个大型项目和1个SCOR。然而，在这些领域，并没有有组织的培养博士后和博士生的计划。我们认为，止血和血栓研究在我们校园的进一步发展需要这样的培训结构。受训者可能追求的特定兴趣领域包括各种凝血因子的结构/功能；血友病的基因治疗；体外和小鼠模型血小板生物学研究；血管系统的发育与病理生物学；以及诸如血栓病和肝素诱导的血小板减少症等临床疾病的分子基础。这项拟议的培训资助将具有几个关键特征，这将使其成为培训止血和血栓形成方面未来研究人员的有效机制。第一个组成部分是一个组织良好的监督委员会，它将确保优秀的受训人员候选人不仅在研究方面取得成功，而且在止血和血栓形成领域获得全面培训。第二个组成部分是设计一个必要的教学系列讲座，使博士实习生对止血和血栓形成的临床方面有全面的了解，并为医学博士实习生提供全面的接触这些领域的各种基础科学问题和方法的机会。另一门必修课程是由国内和国际公认的研究人员举办的心血管系列研讨会。学员将有一个独特的机会，不仅可以听到他们的研究研讨会，还可以在与研究者的特别会议上讨论这些研究者的研究工作。第三个组成部分是半年度评估表格，当学员在研究工作或课程作业中遇到问题时，监督委员会可以尽早进行干预。（摘要结束）

DESCRIPTION (Applicant's Abstract) There have been exciting advances in the areas of hemostasis and thrombosis in the past several years. Rapid advances have occurred in the understanding of the molecular basis of diseases, establishment of animal models for these disorders and in their treatment. Investigators at the University of Pennsylvania have made important contributions to these areas. We have a large and growing body of interactive investigators in these fields, but no training grant to support the training of pre- and post-doctoral fellows in hemostasis and thrombosis. At the moment, there are three large Program Projects and one SCOR in the areas of hemostasis and thrombosis on our campus. Yet, there is no organized program for training pre- and post-doctoral fellows in these areas. We believe that the further growth of research in hemostasis and thrombosis on our campus requires such a training structure. Specific areas of interest that trainees might pursue include structure/function of various coagulation factors; gene therapy for the hemophiliacs; platelet biology both in vitro and in murine models; the development and pathobiology of the vascular system; and the molecular basis of such clinical disorders such as thrombophilia and Heparin-Induced Thrombocytopenia This proposed training grant will have several key features that will make it a productive mechanism for training future investigators in hemostasis and thrombosis. The first component is a well-organized Oversight Committee that will ensure that outstanding trainee candidates are not only successful in their research, but in the obtainment of overall training in the fields of hemostasis and thrombosis. The secondcomponent is the design of a required didactic lecture series to provide the Ph.D. trainee with a well-rounded understanding of the clinical aspects of hemostasis and thrombosis and to provide the M.D. trainee with a well-rounded exposure to the various basic science issues and approaches in these fields. Another required course is the Cardiovascular Seminar Series given by national and internationally recognized investigators. The trainees will be provided with a unique opportunity to not only hear their research seminars, but to discuss the research effort by these investigators in a special session of trainees with investigator. The third component is a semi- annual evaluation form that will allow the Oversight Committee to intervene early when a trainee is having problems in either their research effort or course work. (End of Abstract)