Facility Airborne Biological Toxin Alarm System

设施空气生物毒素报警系统

• 批准号: 7082478
• 负责人: John A Parrish
• 金额: $ 49.2万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7082478
• 关键词: aerosols; air pollution control; bioinformatics; biomedical equipment development; biomedical facility; field study; monitoring device; time resolved data; toxin

This project will develop a real-time, on-site sensor to protect indoor air environments against accidental or ntentional release of biological toxins. The Facility Airborne Biological Toxin Alarm System (FABTAS) is a esearch program of the Biodefense Program at the Center for Integration of Medicine and Innovative Technology (CIMIT) at Massachusetts General Hospital, and the Botulism Research Laboratory at University of Massachusetts Dartmouth (UMD). In this project, a Field Asymmetric Ion Mobility Spectrometer (FAIMS) detector will be coupled with pattern recognition software to allow for immediate recognition of biological toxin signatures hidden within the biological background present in indoor air handling (HVAC) systems. At the conclusion of this 12-month project, CIMIT will produce an easily integrated, low cost, high-sensitivity detector to alert against the presence of biological toxins in indoor air environments. In addition to protecting against intentional biological toxin attacks, the detection system will detect more routine threats to indoor lealth such as molds and fungi (Aspergillus) and bacteria (Legionella). These tasks will be accomplished by first generating ion signatures profiles of non-hazardous simulants that mimic the protypic biological toxins botulism, ricin, saxitoxin and ET-B. Following optimization of signatures for the non-hazarous toxin proxies the system will repeat signature characterization in UMASS-Dartmouth's secure BL3 facility using approved ow concentrations of inactivated biological toxins. Following completion of signature characterization of inactivated toxins the team will attach the FAIMS to a microfluidics transport and commercial "off the shelf air sampling system that that has been successfully used in other FAIMS based chemical HVAC protection projects and the new prototype will be installed in CIMIT's test HVAC system. During this extended field test the false positive alarm rates, reliability, ease of service and cost of maintanance of the FABTAS will be assessed under realistic field conditions. Following the field test, the FABTAS performance parameters will be reviewed and necessary modifications in the FABTAS will be implmented. This project meets the goals of CDC-supported research by generating new technologies, methodologies and diagnostic signature libraries which can be used to improve the immediate detection, mitigation and prevention of bioterrorism or naturally-occuring infection (or allergies) in indoor air environments.

该项目将开发一种实时、现场传感器，以保护室内空气环境免受意外或有意释放的生物毒素的影响。设施空气生物毒素警报系统(FABTAS)是麻省总医院医学与创新技术集成中心(CIMIT)和马萨诸塞大学达特茅斯大学(UMD)肉毒杆菌中毒研究实验室生物防御计划的研究项目。在该项目中，场不对称离子迁移率光谱仪(FAIMS)探测器将与模式识别软件相结合，以允许立即识别隐藏在室内空气处理(HVAC)系统中生物背景中的生物毒素特征。在… 在这个为期12个月的项目结束后，CIMIT将生产一种易于集成、低成本、高灵敏度的探测器，以警告室内空气环境中存在生物毒素。除了防范故意的生物毒素攻击外，该检测系统还将检测到更多对室内健康的常规威胁，如霉菌和真菌(曲霉)和细菌(军团菌)。这些任务将首先通过生成非危险模拟物的离子特征曲线来完成，这些模拟物模仿典型的生物毒素--蓖麻毒素、甲壳虫毒素和ET-B。遵循对非危险毒素代理的签名的优化 该系统将在华盛顿大学达特茅斯分校的安全BL3设施中使用批准的低浓度灭活生物毒素重复签名表征。在完成灭活毒素的特征表征后，团队将把FAIMS安装到已在其他FAIMS化学暖通空调保护项目中成功使用的微流体运输和商业现成的空气采样系统上，新原型将安装在CIMIT的测试暖通空调系统中。在这次扩展的现场测试中，FABTAS将在现实的现场条件下评估假阳性报警率、可靠性、服务便利性和维护成本。现场测试后，FABTAS的性能参数将 将对FABTAS进行审查，并对其进行必要的修改。 该项目通过产生新的技术、方法和诊断标志库来满足疾控中心支持的研究的目标，这些新技术、方法和诊断特征库可用于改进对室内空气环境中的生物恐怖主义或自然发生的感染(或过敏)的即时检测、缓解和预防。