Postdoctoral Training in Medical Genetics

简介（由申请人提供）：我们提出一个博士后项目，提供医学遗传学方面的研究培训。该方案的主要目标是培训医学遗传学研究方面的医生，使他们能够成为人类遗传疾病的独立研究者和学术和科学领袖。该项目的一个特别和独特的优势是UCSF医学遗传学的临床和研究活动的整合，导致研究实习生与临床遗传学的实习生和教师之间的互动。因此，研究受训者可以获得尽可能广泛的背景知识，在此基础上制定和发展未来的研究问题。培训计划的主要组成部分（约80%）是在项目学院调查员的监督下进行明确定义的实质性研究项目。培训师资包括来自临床和基础科学部门的研究人员。培训学院的研究活动非常多样化，包括基础研究、临床实验室研究和流行病学研究：生物化学遗传学、癌症遗传学、心血管发育遗传学、胎儿发育和出生缺陷、基因治疗、复杂疾病遗传学、耳聋遗传学、遗传性皮肤病、基因组学和信息学、血红蛋白病、免疫遗传学、肝病、脂蛋白疾病、分子细胞遗传学、药物遗传学、性染色体生物学、哺乳动物、果蝇和斑马鱼发育遗传学。该培训计划的教师在遗传学的博士前和博士后培训方面有着出色的记录，令人印象深刻的实验室设施，并为他们的研究提供了大量的资金。因此，该学院可以为该计划下博士后学员的成功研究培训提供空间，实验室资源和规划环境。培训方案的其他组成部分包括参加预定的研究和医学遗传学会议；研究生水平的研究方法、基础遗传学和高级人类遗传学课程；在临床和临床实验室遗传学方面有针对性的指导。绝大多数申请者和入选者都是对医学遗传学研究事业感兴趣的内科医生（医学博士或医学博士）。该计划还能够容纳对医学遗传学研究，教学和临床实验室职业感兴趣的科学家（博士）。该项目在加州大学旧金山分校由一名项目主任和一个咨询小组监督，该小组定期评估和监督学员的进展。最后，该项目将从目前对加州大学旧金山分校人类遗传学学术存在的广泛扩展和增强的承诺中受益匪浅。

DESCRIPTION (provided by applicant): We propose a postdoctoral Program to provide research training in medical genetics. The primary objective of the program is the training of physicians in research in medical genetics, to enable them to become independent investigators, and academic and scientific leaders in human genetic disease. An especial and unique strength of the Program is the integration of clinical and research activities in medical genetics at UCSF, resulting in the interactions of research trainees with trainees and faculty in clinical genetics. Research trainees are thereby provided with the broadest possible background upon which to formulate and develop future research problems. The major component (about 80%) of the Training Program is the conduct of a clearly defined and substantive research project under the supervision of a Program Faculty investigator. The Training Faculty includes investigators from both clinical and basic science departments. The research activities of the Training Faculty are truly diverse, and include basic, clinical laboratory, and epidemiologic research in: biochemical genetics, cancer genetics, cardiovascular developmental genetics, fetal development and birth defects, gene therapy, the genetics of complex disorders, the genetics of deafness, genodermatoses, genomics and informatics, hemoglobinopathies, immunogenetics, liver disease, lipoprotein disorders, molecular cytogenetics, pharmacogenetics, sex chromosome biology, and mammalian, Drosophila and zebra fish developmental genetics. Faculty members of this Training Program have an excellent record in pre-and post-doctoral training in genetics, impressive laboratory facilities, and extensive funding for their research. This faculty can therefore provide the space, laboratory resources, and programmatic environments for the successful research training of postdoctoral trainees under this Program. Additional components of the Training Program include attendance at scheduled research and medical genetics conferences; graduate level courses in research methodology and in basic genetics and advanced human genetics; and targeted instruction in clinical and clinical laboratory genetics. The vast majority of applicants and entrants are physicians (MD or MD-Ph.D.)) interested in research careers in medical genetics. The Program has also been able to accommodate scientists (Ph.D.) interested in research, teaching, and clinical laboratory careers in medical genetics. The Program is overseen at UCSF by a Program Director and an Advisory Group, who regularly evaluates and monitors the progress of trainees. Finally, the Program will immeasurably benefit from the current commitment to the broad expansion and enhancement of the academic presence of human genetics at UCSF.