CARDIOVASOLOGY

(申请人--S摘要) 此续期申请代表对26至30年的资金申请 我们的培训基金名为心血管病。这一培训计划一直是 非常成功地为个人的独立研究生涯做好准备 在心血管医学和生物学方面，我们目前的应用是 其特点是越来越重视翻译研究，这带来了 一支由老牌调查人员组成的跨学科团队。建议数 培训计划的重点是心力衰竭和缺血综合征 心脏病。这两个相互关联的主题是基于 目前教职员工的专业知识，这两种疾病所起的中心作用 美国人口中的实体，更具体地说，是 梅奥诊所。关注心力衰竭的另一个理由是 缺血性心脏病是指这些复杂的综合征，涉及 多种细胞类型，需要多学科方法，因此 提供强大的机制来汇聚教职员工并提供多样化的 为学员提供研究机会。教职员工由一个协作性的 由基础科学家、内科科学家、临床科学家组成的创新团队 有明确记录的调查人员和人口科学家 辅导。此外，我们已经设计了我们的竞争更新，以满足 与NHLBI“火花”报告的建议并行，因此我们的 教职员工将遗传学、细胞生物学、研究培训 组织和整个动物水平与人类生理学和种群科学。 培养具有创新精神的人才是我们竞争重生的目标 生物学和对创新方法的重视，这将促进 翻译对心血管疾病病理生理学的理解 疾病导致了新的诊断和治疗方法。以我们目前的情况 我们提出了充满活力、才华横溢的多学科 一组经验丰富的调查人员，他们拥有有记录的指导技能和 唱片。培训方案教职员工所代表的当前技术 包括分子遗传学、药物基因组学、功能基因组学 流行病学和结局研究、基因治疗和移植生物学 它们补充了传统的内科、儿科、 外科、药理学、生理学、生物化学和分子生物学。因此， 学员将接触到围绕以下方面组织的多种技术 心力衰竭和缺血性心脏病的翻译主题。基本原理 对这一努力仍然毫无保留地致力于学员的多样性和 教职员工除了敬业之外，还有卓越的承诺。我们相信我们的 竞争性更新制定了一项战略，以延续这一传统 在心血管生物学和医学方面的研究培训方面表现出色。

(Applicant?s Abstract) This renewal application represents a request for funding for years 26 to 30 of our training grant entitled Cardiovasology. This training program has been highly successful in preparing individuals for an independent research career in cardiovascular medicine and biology, and our current application is characterized by an increasing focus upon translational research that brings together an interdisciplinary team of established investigators. The proposed training program is focused upon the syndromes of heart failure and ischemic heart disease. These two interrelated themes were chosen based upon the current expertise of the faculty, the central role played by these two disease entities in the US population and more specifically the patient population at the Mayo Clinic. An additional rationale for focusing upon heart failure and ischemic heart disease is that these are complex syndromes which involve multiple cell types, require multidisciplinary approaches and therefore provide a powerful mechanism to bring together the faculty and provide diverse research opportunities for trainees. The faculty consists of a collaborative and innovative team of basic scientists, physician-scientists, clinical investigators and population scientists with established track records in mentoring. Moreover, we have designed our competitive renewal to be in parallel with recommendations of the NHLBI "SPARKS" report and therefore our faculty incorporates genetics, cellular biology, research training at the tissue and whole animal level with human physiology and population sciences. It is the goal of our competitive renewal to train talented individuals in new biology and an emphasis upon innovative methodologies that will facilitate translation in the understanding of the pathophysiology of cardiovascular disease leading to novel diagnostics and therapeutics. With our current competitive renewal we propose a vibrant and highly talented multidisciplinary group of established investigators with documented mentoring skills and records. Current technologies represented in the training program faculty include molecular genetics, pharmacogenomics, functional genomics, epidemiology and outcomes research, gene therapy and transplantation biology which complement traditional departments of internal medicine, pediatrics, surgery, pharmacology, physiology, biochemistry and molecular biology. Thus, trainees are exposed to multiple technologies that are organized around the translational themes of heart failure and ischemic heart disease. Fundamental to this effort remains an unreserved commitment to diversity of trainees and faculty in addition to the commitment excellence. We believe that our competitive renewal lays down a strategy to continue this tradition of excellence in research training in cardiovascular biology and medicine.