Radiation Therapy Impact on Structure/Mechanics of Teeth

放射治疗对牙齿结构/力学的影响

• 批准号: 6915837
• 负责人: MARY P WALKER
• 金额: $ 13.14万
• 依托单位: UNIVERSITY OF MISSOURI KANSAS CITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6915837
• 关键词: biomechanics; clinical research; computer simulation; dental caries; dental occlusion; dental stress analysis; dentin; head /neck neoplasm; human subject; microscopy; mouth neoplasms; neoplasm /cancer radiation therapy; patient oriented research; radiation therapy dosage; radioprotective agents; salivary glands; statistics /biometry; therapy adverse effect; tooth; tooth enamel; xerostomias

DESCRIPTION (provided by applicant): This proposal for a Mentored Patient-Oriented Research Career Development Award (K23) application is divided into didactic, applied clinical and translational research components. The didactic component will provide educational experiences to allow the principal investigator to design, conduct, and analyze patient-oriented research. A detailed instructional plan is described in the application. The clinical and translational research training component will provide the candidate an opportunity to work closely with experienced clinical and basic science investigators. The project will combine 1) in vivo, retrospective assessment of the severity of any postradiation dental lesions as related to factors such as radiation field parameters, the radiation dose to which teeth were exposed, and the use of salivary gland radiation protector drugs; 2) in vitro chemical, mechanical, and morphologic analyses of structure and properties of in vivo irradiated teeth as compared to non-irradiated teeth; 3) the structure/property relationships will be used in finite element modeling of the stress distribution within irradiated teeth under simulated functional loading conditions; 4) developing the infrastructure and acquiring the preliminary data to continue the investigation as a prospective, longitudinal clinical trial for future grant applications in order to correlate the initiation and progression of post-radiation dental lesions to additional clinical factors such as xerostomia and occlusal patterns, as well as radiation dose, field parameters, and the use radiation protector drugs. This project will enable the candidate to obtain research skills in the following areas: 1) retrospective and prospective methodology in the clinical evaluation of patient factors related to therapeutic radiation-induced dental lesions; 2) laboratory evaluation of the associated changes in the structure and properties of teeth exposed to therapeutic radiation; 3) finite element calculation and modeling of stress distribution patterns that develop in these teeth under simulated functional loading. By completing the objectives outlined in the project, Dr. Walker will develop skills necessary to function as an independent clinical researcher and have the opportunity to collaborate with basic scientists to gain insight into how laboratory analyses can be incorporated into patient-based investigations. A key strength of this project is the associated feedback mechanism that relates the clinical problem to both clinical and laboratory data, the integration of scientific principles into clinical practice.

描述（由申请人提供）：本提案为指导患者为导向的研究职业发展奖（K23）应用分为教学，应用临床和转化研究组件。教学部分将提供教育经验，使主要研究者设计，进行和分析以患者为导向的研究。申请书中描述了详细的教学计划。临床和转化研究培训部分将为候选人提供与经验丰富的临床和基础科学研究人员密切合作的机会。该项目将结合联合收割机：1）在体内，回顾性评估任何辐射后牙齿损伤的严重性，这些损伤与辐射场参数、牙齿所受辐射剂量和唾液腺辐射保护药物的使用等因素有关; 2）与未受辐射牙齿相比，对体内受辐射牙齿的结构和性能进行体外化学、机械和形态学分析; 3）结构/性能关系将用于模拟功能性负载条件下辐照牙齿内的应力分布的有限元建模; 4）发展基础设施并获取初步数据，以继续进行前瞻性调查，纵向临床试验，为未来的赠款申请，以相关的启动和进展后，放射性牙损害与其他临床因素如口干和咬合模式，以及辐射剂量、射野参数和使用辐射防护药物有关。该项目将使候选人获得以下领域的研究技能：1）与治疗性辐射诱导的牙齿损伤相关的患者因素的临床评价的回顾性和前瞻性方法; 2）暴露于治疗性辐射的牙齿的结构和性质的相关变化的实验室评价; 3）有限元计算和模拟功能载荷下这些牙齿中产生的应力分布模式的建模。通过完成项目中概述的目标，步行者博士将发展作为独立临床研究人员所需的技能，并有机会与基础科学家合作，深入了解如何将实验室分析纳入基于患者的调查。该项目的一个关键优势是相关的反馈机制，将临床问题与临床和实验室数据联系起来，将科学原理融入临床实践。