Asymmetric Epoxidation of Olefins by Chiral Dioxiranes

描述(申请人提供)：拟议研究的总体目标是探索手性二氧六环的机理特征和合成潜力。本研究的具体目的是：(1)了解手性二氧六环催化烯烃不对称环氧化反应的机理和过渡态；(2)进一步设计和寻找具有高稳定性、高活性和高对映体选择性的新型酮催化剂；(3)探索和扩大二氧六环催化不对称环氧化反应的范围；(4)将新开发的不对称环氧化反应应用于合成有用的手性结构单元和生物活性化合物。

DESCRIPTION (provided by applicant): The overall goal of the proposed research is to explore the mechanistic features and synthetic potential of chiral dioxiranes. The specific aims of the proposed research are: (1) to understand the mechanism and transition states involved in asymmetric epoxidation of olefins by chiral dioxiranes; (2) to further design and search for new ketone catalysts with high stability, reactivity, and enantioselectivity; (3) to explore and expand the scope of dioxirane-mediated asymmetric epoxidation; (4) to apply the newly developed asymmetric epoxidation to the synthesis of useful chiral building blocks and biologically active compounds.