High Frequency Ultrasound Arrays : Intracardiac Imaging

高频超声阵列：心内成像

• 批准号: 6844323
• 负责人: David J. Sahn
• 金额: $ 151.28万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-15 至 2007-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6844323
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; diagnosis design /evaluation; echocardiography; epicardial mapping; heart catheterization; heart disorder diagnosis; heart electrical activity; heart sonography; human subject; patient oriented research; swine

DESCRIPTION (provided by applicant): lnvasive applications of echocardiography, including transesophageal echo, intravascular echo and intracardiac echo have been one of the most fertile areas driving new technology for ultraminiaturization and very high resolution. Among the most prolonged and detailed interventional catheterization procedures, electrophysiological mapping and ablation for recurrent atrial and ventricular arrhythmias have received recent attention because of the now-recognized need for spatial mapping in addition to fluoroscopic catheter localization, and because of the increased frequency of these debilitating rhythm problems in an aging population. We propose to design, develop and test a family of 2D and 3D ultrasound imaging devices which, at 10-15MHz operating frequency, will provide spatial localization, and both tissue velocity and strain rate estimates of mechanical activation in atrial and ventricular walls, to guide electrical mapping. This should greatly shorten time to localize critical areas. Our devices will be integrated with the EP electrode and RF ablation devices so that they can anatomically monitor the ablation procedure, visualize the lesion, and map the distribution of temperature during RF delivery focus. The devices we will build can also assess the heart before, during and after surgery as well as monitor anatomical catheter interventions for coronary artery, valvular or congenital heart disease. Our partnership is a multidisciplinary group of clinicians, surgeons, echocardiographers and electrophysiologists at OHSU, led by David J. Sahn, MD, Director of the Interdisciplinary Program For Cardiac Imaging, combined with bioengineers including: Matthew O'Donnell, PhD, Chair of the Department of Biomedical Engineering at the University of Michigan, Ann Arbor; Kirk Shung, PhD, director of an NIH Research Resource for Development of High Frequency Arrays at Pennsylvania State University, University Park; Kal Thomenius, PhD, Program Manager of Ultrasound Research at the General Electric Corporate Research and Development Center in Schenectady, New York; Douglas Stephens, Vice President of Strategic Technology at the Imaging Division of JOMED (formerly Endosonics Corporation) in Rancho Cordova, California, a pioneer in miniaturized array devices for intravascular and intracardiac imaging catheters; and Raymond Chia, PhD, of Irvine Biomedical, a small agile company with expertise in steerable multipolar electrode and ablation devices and their combination with other imaging modalities. The design and development of these devices combined with advanced functional imaging methods should open new vistas for applications in invasive echocardiography and ultrasound in general.

描述（由申请人提供）：超声心动图的侵入性应用， 包括经食管回声、血管内回声和心内回声， 是推动新技术发展的最肥沃的领域之一， 超小型化和非常高的分辨率。其中最长的， 详细的介入性导管插入术，电生理学 针对复发性房性和室性心律失常的标测和消融， 最近受到关注，因为现在认识到需要空间 除了荧光透视导管定位外， 这些衰弱的节奏问题的频率增加， 人口我们建议设计，开发和测试一系列2D和3D 超声成像设备，在10- 15 MHz的工作频率，将提供 空间定位，以及组织速度和应变率估计， 心房和心室壁中的机械激活，以引导电 映射.这将大大缩短定位关键区域的时间。我们 设备将与电生理电极和射频消融设备集成， 他们可以在解剖学上监测消融过程， 损伤，并绘制射频输送聚焦期间的温度分布。的 我们将制造的设备也可以在心脏病发作前、发作中和发作后 外科手术以及监测用于冠状动脉 动脉、瓣膜或先天性心脏病。我们的合作关系是 由临床医生、外科医生、超声心动图技师和 OHSU的电生理学家，由医学博士大卫J. Sahn领导， 心脏成像跨学科计划，结合生物工程师 包括：Matthew奥唐纳博士，生物医学系主任 密歇根大学工程学，安阿伯; Kirk Shung，博士，主任 美国国立卫生研究院的研究资源，用于开发高频阵列， 宾夕法尼亚州立大学，大学公园; Kal Thomenius，博士，项目 General Electric Corporate Research和 纽约谢内克塔迪发展中心;副总裁道格拉斯斯蒂芬斯 JOMED（前身为Endosonics）成像部门的战略技术 公司），加州小型阵列的先驱 用于血管内和心内成像导管的装置;以及Raymond Chia， Irvine Biomedical的博士，Irvine Biomedical是一家小型敏捷公司，拥有可操纵的专业知识 多极电极和消融装置以及它们与其它 成像方式。这些设备的设计和开发结合了 先进的功能成像方法将为以下应用开辟新的前景： 侵入性超声心动图和一般超声。