The role of cortico-hippocampal interaction in memory consolidation

皮质-海马相互作用在记忆巩固中的作用

基本信息

  • 批准号:
    2549527
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Studentship
  • 财政年份:
    2021
  • 资助国家:
    英国
  • 起止时间:
    2021 至 无数据
  • 项目状态:
    未结题

项目摘要

System memory consolidation is a brain-wide process that transforms recently encodedliable memories into more stable and long-term memories. The 'two-stage' theory ofmemory process posits that memory consolidation engages bi-directional dialogueduring offline state between the hippocampus, where memory traces are initiallyformed, and the neocortex, where memory traces are eventually stored for long-termretention. During active exploration of a spatial context, sub-populations of neurons inboth CA1 region of hippocampus (HPC) and primary visual cortex (V1) develop spatialsensitivity with experience such that those spatially-modulated neurons would beactivated sequentially along animal's running trajectory. Strikingly, during offline period,the neuronal sequences observed in both regions during active spatial experience can bereplayed in a spatiotemporally coordinated fashion. Disruption of such replay inhippocampus would impair spatial memory performance. These observations led to thepossibility that interaction between the hippocampus and the neocortex around thetime of coherent replay may be instrumental to memory consolidation. However, as oftoday, we are unclear about the nature and direction of cortico-hippocampalinformation flow around the time of replay. Previous evidence suggested that change inneocortical activity can precede replay events. Nevertheless, it is unknown if the V1activity patterns prior to a replay event can selectively influence the memory content toreplay in both hippocampus and V1. Furthermore, we do not know whetherimprovement in coherence of hippocampal-cortical interaction during post-trainingreplay predict the memory performance and fidelity of the learned spatial informationin the V1.To address these research questions, we aim to record from V1 and CA1 of HPC whilemice learn to discriminate two novel linear tracks in virtual reality (VR). Two VR lineartracks with visually-identical landmarks in two positions will be used to trackdevelopment of spatial modulation in V1 over time. We will also train the animal to lickfor a reward when reaching a designated reward zone for each linear track, whichencourages animals to actively discriminate between two linear tracks. By recording V1and CA1 neural activities during multiple learning sessions and post-learning restsessions over the course of several weeks, we would like to examine how replaydynamics and cortico-hippocampal interactions during replay change as thediscriminatory memory performance improves over time.
系统记忆巩固是一个全脑过程,它将最近可编码的记忆转化为更稳定和长期的记忆。记忆过程的“两阶段”理论认为,记忆巩固在离线状态下进行双向对话,海马体是最初形成记忆痕迹的地方,而新皮质是记忆痕迹最终被存储以长期保留的地方。在主动探索空间环境的过程中,海马 CA1 区 (HPC) 和初级视觉皮层 (V1) 的神经元亚群随着经验的积累而发展出空间敏感性,使得这些空间调制的神经元将沿着动物的跑步轨迹顺序激活。引人注目的是,在离线期间,在主动空间体验期间在两个区域观察到的神经元序列可以以时空协调的方式重播。海马体中这种重放的破坏会损害空间记忆的表现。这些观察结果表明,在连贯重放期间海马体和新皮质之间的相互作用可能有助于记忆巩固。然而,到目前为止,我们还不清楚重放期间皮质海马信息流的性质和方向。先前的证据表明,新皮质活动的变化可能先于重放事件。然而,尚不清楚重放事件之前的 V1 活动模式是否可以选择性地影响海马体和 V1 中重放的记忆内容。此外,我们不知道训练后重放过程中海马-皮质相互作用一致性的提高是否可以预测 V1 中学习的空间信息的记忆性能和保真度。为了解决这些研究问题,我们的目标是在小鼠学会区分虚拟现实 (VR) 中的两个新颖线性轨迹的同时,从 HPC 的 V1 和 CA1 进行记录。两个 VR 线性轨道在两个位置上具有视觉上相同的地标,将用于跟踪 V1 中空间调制随时间的发展。我们还将训练动物在到达每个线性轨道的指定奖励区域时舔舐奖励,这鼓励动物主动区分两个线性轨道。通过在几周的时间内记录多次学习过程和学习后休息过程中的 V1 和 CA1 神经活动,我们希望研究重放过程中重放动态和皮质-海马相互作用如何随着歧视性记忆性能随时间的推移而变化。

项目成果

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Internet-administered, low-intensity cognitive behavioral therapy for parents of children treated for cancer: A feasibility trial (ENGAGE).
针对癌症儿童父母的互联网管理、低强度认知行为疗法:可行性试验 (ENGAGE)。
  • DOI:
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Differences in child and adolescent exposure to unhealthy food and beverage advertising on television in a self-regulatory environment.
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  • DOI:
    10.1186/s12889-023-15027-w
  • 发表时间:
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The association between rheumatoid arthritis and reduced estimated cardiorespiratory fitness is mediated by physical symptoms and negative emotions: a cross-sectional study.
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  • DOI:
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  • DOI:
    10.1186/s12859-023-05245-9
  • 发表时间:
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  • 期刊:
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Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly.
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  • DOI:
    10.1039/d2nh00424k
  • 发表时间:
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  • 期刊:
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  • 作者:
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的其他文献

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核燃料模拟物的现场辅助烧结
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    2908917
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    2027
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