Clinical Assessment of Herb-Drug Interactions
草药-药物相互作用的临床评估
基本信息
- 批准号:6941693
- 负责人:
- 金额:$ 30.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-09-30 至 2007-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (provided by applicant): Adverse drug-drug interactions stemming from the induction or inhibition of cytochrome P-450 enzymes and/or the multidrug efftux pump, P-glycoprotein, are well recognized. With the widespread use of herbal dietary supplements, the potential for herb-drug interactions is emerging as a significant medical concern. Recent surveys indicate that 45 million Americans use herbal remedies regularly and that nearly 1 in 5 individuals taking prescription medications are also taking herbal supplements. This translates into more than 15 million adults taking prescription medications concurrently with herbal supplements. Furthermore, it has been noted that 70% of patients do not reveal their herb use to primary care providers. The risk of potential herb-drug interactions, therefore, is considerable. Documented herb-drug interactions are being reported in the medical literature. While a few in vivo studies indicate that the phytochemical components of botanical medicines can modulate hepatic drug metabolizing enzymes (cytochrome P-450s, CYP), and the multidrug efflux pump, P-glycoprotein (P-gp), no prospective in vivo studies assessing herb-drug interactions or their underlying mechanisms have been conducted in humans. The hypothesis to be tested is that concomitant use of herbal dietary supplements and conventional medications can elicit herb-drug interactions secondary to herb-mediated changes in drug absorption and elimination. The current proposal will evaluate changes in apparent oral clearance of phenotypic probe drugs as a means of assessing the effect of prolonged herbal supplementation on hepatic and intestinal CYP and/or P-gp activity in humans. The goals of this project are: (1) to assess which, if any, of 10 top-selling herbs in the United States pose a risk for CYP-mediated and/or P-gp-mediated herb-drug interactions; (2) to determine if prolonged berba| supplement use modulates specific CYP activities (i.e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination.
描述(由申请方提供):由于诱导或抑制细胞色素P-450酶和/或多药外排泵、P-糖蛋白而引起的药物间不良相互作用已得到充分认可。随着草药膳食补充剂的广泛使用,草药-药物相互作用的可能性正在成为一个重要的医学问题。最近的调查表明,4500万美国人经常使用草药,近五分之一服用处方药的人也服用草药补充剂。这意味着超过1500万成年人同时服用处方药和草药补充剂。此外,70%的患者没有向初级保健提供者透露他们的草药使用情况。因此,潜在的草药相互作用的风险是相当大的。在医学文献中报告了记录在案的草药-药物相互作用。虽然一些体内研究表明,植物药的植物化学成分可以调节肝脏药物代谢酶(细胞色素P-450,CYP 1A 1)和多药外排泵,P-糖蛋白(P-gp),没有前瞻性的体内研究评估草药-药物相互作用或其潜在的机制已在人类中进行。待检验的假设是,同时使用草药膳食补充剂和常规药物可引起继发于草药介导的药物吸收和消除变化的草药-药物相互作用。目前的提案将评估表型探针药物的表观口服清除率的变化,作为评估长期草药补充对人类肝脏和肠道炎症和/或P-gp活性的影响的一种手段。本项目的目的是:(1)评估美国10种最畅销的草药中哪些(如果有的话)会对CYP介导和/或P-gp介导的草药-药物相互作用造成风险;(2)确定是否存在长期的小檗碱依赖性。|补充剂的使用调节特定的Pgp活性(即CYPIA 2、CYP 2D 6和CYP 3A 4);和(3)长期使用草药是否可以调节P-gp介导的药物吸收和消除。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Bill Gurley其他文献
Bill Gurley的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Bill Gurley', 18)}}的其他基金
In vitro screening of a unique botanical extract collection for herb-drug interaction (HDI) potential
体外筛选独特的植物提取物集合的草药-药物相互作用 (HDI) 潜力
- 批准号:
10226906 - 财政年份:2020
- 资助金额:
$ 30.53万 - 项目类别:
AGING AND CYP-MEDIATED HERB-DRUG INTERACTIONS
衰老和 CYP 介导的草药-药物相互作用
- 批准号:
6050796 - 财政年份:1999
- 资助金额:
$ 30.53万 - 项目类别:
相似海外基金
Complementary and alternative medicine for drug-induced gingival overgrowth: inhibitory effect of TRPA1 channel by lutein
药物性牙龈增生的补充和替代医学:叶黄素对 TRPA1 通道的抑制作用
- 批准号:
23K09321 - 财政年份:2023
- 资助金额:
$ 30.53万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Complementary alternative medicine contributes to attenuate orofacial pain: anesthetic and anti-inflammatory effects of phytochemical
补充替代医学有助于减轻口面部疼痛:植物化学物质的麻醉和抗炎作用
- 批准号:
22K10232 - 财政年份:2022
- 资助金额:
$ 30.53万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Negotiating distinctions between conventional and alternative medicine in the English- and French-language Wikipedias
英语和法语维基百科中讨论传统医学和替代医学之间的区别
- 批准号:
AH/V013203/1 - 财政年份:2021
- 资助金额:
$ 30.53万 - 项目类别:
Research Grant
Systematic study on legal regulations for complementary and alternative medicine
补充替代医学法律法规的系统研究
- 批准号:
19K21680 - 财政年份:2019
- 资助金额:
$ 30.53万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Contribution of complementary alternative medicine to the orthodontic tooth-movement induced inflammatory pain: a possible role of dietary constituent
补充替代医学对正畸牙齿移动引起的炎症性疼痛的贡献:饮食成分的可能作用
- 批准号:
19K10415 - 财政年份:2019
- 资助金额:
$ 30.53万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Application of complementary and alternative medicine for breast cancer based on kinetic characteristics of food components
基于食物成分动力学特征的乳腺癌补充替代医学应用
- 批准号:
18K14416 - 财政年份:2018
- 资助金额:
$ 30.53万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Elucidation of the Mechanism of Care Effectiveness Using Complementary and Alternative Medicine Material Detergent for Radiation Skin Damage
阐明补充和替代药物材料清洁剂对放射性皮肤损伤的护理效果机制
- 批准号:
18K17460 - 财政年份:2018
- 资助金额:
$ 30.53万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Quality of clinical research papers on complementary and alternative medicine: evaluation with modified systematic reviews
补充和替代医学临床研究论文的质量:用修改后的系统评价进行评估
- 批准号:
17K08938 - 财政年份:2017
- 资助金额:
$ 30.53万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Formulation for the Application of the Energy Therapy "Reiki" as Complementary and Alternative Medicine for Cancer Patient
应用能量疗法“灵气”作为癌症患者的补充和替代医学的配方
- 批准号:
16K15906 - 财政年份:2016
- 资助金额:
$ 30.53万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Boundaries between Orthodox Medicine and Alternative Medicine
正统医学与替代医学之间的界限
- 批准号:
16K21422 - 财政年份:2016
- 资助金额:
$ 30.53万 - 项目类别:
Grant-in-Aid for Young Scientists (B)