Alzheimer's Disease Genes, Cellular Pathways and Therapies

描述（由申请人提供）：阿尔茨海默病（AD）是一种进行性神经退行性疾病，是老年痴呆症最常见的形式。在过去的二十年中，从遗传、分子和细胞生物学水平对阿尔茨海默病的研究已经揭示了影响该病发病机制的大量基因、蛋白质和生物学途径。这些致病途径的特征表明了几种有希望的治疗和预防AD的治疗策略，这些策略基于抑制大脑中Abeta肽的积累，调节tau过度磷酸化，调节炎症反应和增强神经递质功能。本次会议将涵盖阿尔茨海默病遗传学的最新进展，β的产生和清除途径，tau的调控，相关动物模型，新的治疗策略，以及阿尔茨海默病诊断的成像和生物标志物的进展。阿尔茨海默病（AD）及相关疾病是老年人群中最常见的痴呆症形式。老年痴呆症的两个最大风险因素是年龄增长和家族史。随着平均寿命的持续增长，特别是在西方世界，阿尔茨海默病代表了医疗保健系统最大的负担之一。本次研讨会将重点讨论阿尔茨海默病和额颞叶痴呆的遗传风险因素、相关细胞通路和新疗法。

DESCRIPTION (provided by applicant): Alzheimer's disease (AD), a progressive neurodegenerative disease, is the most common form of dementia in the elderly. Over the past two decades, studies of AD at the genetic, molecular, and cell biological level have revealed a host of genes, proteins, and biological pathways that impact on the pathogenesis of this disease. Characterization of these pathogenic pathways has suggested several promising therapeutic strategies for treating and preventing AD based on curbing the accumulation of the Abeta peptide in brain, regulating tau hyperphosphorylation, modulating inflammatory responses, and enhancing neurotransmitter function. This meeting will cover updates of the genetics of AD, Abeta generation and clearance pathways, regulation of tau, relevant animal models, novel therapeutic strategies, and advances in imaging and biomarkers for AD diagnosis. Alzheimer's disease (AD) and related disorders are the most common forms of dementia in the elderly population. The two greatest risk factors for AD are advancing age and family history. As the average lifespan continues to increase, particularly in the Western world, AD represents one of the single greatest burdens on the healthcare system. This symposium will focus on genetic risk factors, relevant cellular pathways and emerging therapies for AD and frontal temporal dementia.