Alzheimer's Disease Genes, Cellular Pathways and Therapies

阿尔茨海默病基因、细胞通路和治疗

• 批准号: 7001149
• 负责人: RUDOLPH Emile TANZI
• 金额: $ 1.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7001149
• 关键词: Alzheimer' s disease; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): Alzheimer's disease (AD), a progressive neurodegenerative disease, is the most common form of dementia in the elderly. Over the past two decades, studies of AD at the genetic, molecular, and cell biological level have revealed a host of genes, proteins, and biological pathways that impact on the pathogenesis of this disease. Characterization of these pathogenic pathways has suggested several promising therapeutic strategies for treating and preventing AD based on curbing the accumulation of the Abeta peptide in brain, regulating tau hyperphosphorylation, modulating inflammatory responses, and enhancing neurotransmitter function. This meeting will cover updates of the genetics of AD, Abeta generation and clearance pathways, regulation of tau, relevant animal models, novel therapeutic strategies, and advances in imaging and biomarkers for AD diagnosis. Alzheimer's disease (AD) and related disorders are the most common forms of dementia in the elderly population. The two greatest risk factors for AD are advancing age and family history. As the average lifespan continues to increase, particularly in the Western world, AD represents one of the single greatest burdens on the healthcare system. This symposium will focus on genetic risk factors, relevant cellular pathways and emerging therapies for AD and frontal temporal dementia.

描述(申请人提供)：阿尔茨海默病(AD)是一种进行性神经退行性疾病，是老年人最常见的痴呆症形式。在过去的二十年里，在遗传、分子和细胞生物学水平上对阿尔茨海默病的研究揭示了一系列影响该病发病机制的基因、蛋白质和生物学途径。对这些致病途径的研究表明，一些有希望的治疗策略可用于治疗和预防AD，其基础是抑制Abeta肽在脑内的积聚，调节tau过度磷酸化，调节炎症反应，以及增强神经递质功能。本次会议将涉及AD的遗传学、Abeta的产生和清除途径、tau的调节、相关的动物模型、新的治疗策略以及用于AD诊断的成像和生物标记物的进展。阿尔茨海默病(AD)和相关疾病是老年人口中最常见的痴呆症形式。AD的两个最大风险因素是高龄和家族史。随着平均寿命的持续增长，特别是在西方世界，AD是医疗体系最大的单一负担之一。本次研讨会将集中讨论阿尔茨海默病和额叶痴呆症的遗传危险因素、相关的细胞通路和新出现的治疗方法。