PEMPHIGUS 2005-PROGRESS AND FUTURE DIRECTIONS

天疱疮 2005-进展和未来方向

• 批准号: 6941033
• 负责人: JEAN-CLAUDE BYSTRYN
• 金额: $ 4万
• 依托单位: INTERNATIONAL PEMPHIGUS PEMPHIGOID FDN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-20 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941033
• 关键词: autoantibody; meeting /conference /symposium; pathologic process; pemphigus; travel

DESCRIPTION (provided by applicant): Pemphigus is a serious blistering disease of the skin. It is a model auto-antibody mediated disease, caused by auto-antibodies against the keratinocyte adhesion molecules desmoglein 1 and 3. Rapid advances are being made understanding the pathogenesis of pemphigus and developing novel approaches to it. The first national conference on this disease was held on the NIH campus 4 years ago and was very successful. We now propose a follow-up conference-- "Pemphigus 2005 - Progress and Future Directions". It will bring together basic scientists and clinical investigators working on the mechanisms of, and novel therapeutic approaches to, human auto-antibody mediated diseases in general and pemphigus specifically. Up-to-date developments in our understanding of the causes and the treatment of pemphigus will be reviewed. The goal will be to identify are as of research opportunity that will most effectively promote our further understanding of the causes and the treatments of pemphigus, and to cross-hybridize ideas on how to reach these goals among interested researchers. The conference will be organized around two major themes, each of one day's duration: 1) Advances in our understanding of the pathogenesis of pemphigus, and 2) advances in the treatment of this disease. Two workshops are planned to establish consensus among workers in the field on the diagnostic criteria for pemphigus and on the parameters used to evaluate the extent, activity, severity and response to therapy of this disease. There will be a poster session for advances that cannot be presented orally at the meeting. The conference is sponsored by two leading national lay organizations- one interested in pemphigus (International Pemphigus Foundation) the other more generally interested in autoimmune diseases (American Autoimmune Related Diseases Association. We expect it will attract 100-150 scientists and clinicians dedicated to investigate and treating pemphigus.

描述（由申请人提供）：天疱疮是一种严重的皮肤起泡疾病。它是一种模型自身抗体介导的疾病，由针对角质形成细胞粘附分子桥粒芯糖蛋白1和3的自身抗体引起。对天疱疮发病机制的认识和新方法的开发正在取得快速进展。4年前在NIH校园举行了第一次关于这种疾病的全国会议，非常成功。我们现在提议召开一次后续会议-“2005年天疱疮-进展和未来方向”。它将汇集基础科学家和临床研究人员，研究人类自身抗体介导的疾病的机制和新的治疗方法，特别是天疱疮。最新的发展，我们的理解的原因和治疗天疱疮将审查。我们的目标将是确定作为研究机会，这将最有效地促进我们进一步了解天疱疮的原因和治疗，并交叉杂交的想法如何在感兴趣的研究人员之间实现这些目标。会议将围绕两个主题组织，每个主题为期一天：1）我们对天疱疮发病机制的理解进展，以及2）这种疾病的治疗进展。计划举办两次讲习班，以便在该领域的工作人员中就天疱疮的诊断标准以及用于评价这种疾病的程度、活动性、严重性和对治疗的反应的参数达成共识。对于无法在会上口头介绍的进展，将举行一次海报会议。该会议由两个领先的全国性非专业组织赞助--一个对天疱疮感兴趣（国际天疱疮基金会），另一个对自身免疫性疾病更感兴趣（美国自身免疫相关疾病协会）。我们预计它将吸引100-150名科学家和临床医生致力于调查和治疗天疱疮。