Molecular Pathology of Lung Cancer

描述(由申请人提供)：本提案的目的是于2005年2月23-27日在加利福尼亚州圣地亚哥组织一次题为“肺癌分子发病机制转化为临床的机会”的科学会议。本次AACR特别会议汇集了在肺癌研究的基础、翻译和临床领域处于领先地位的科学家和医生。在美国和世界上许多国家，肺癌是男性和女性的最大癌症杀手。这次会议集中在许多新的重要的翻译进展，涉及肺癌的各个方面，承诺了一个基本的方法来阻止这种致命的疾病。这些包括：了解其分子发病机制；遗传流行病学；尼古丁成瘾的遗传学和戒烟治疗的反应；早期检测策略，包括分子检测；化学预防；肿瘤和血液的分子图谱(mRNA、蛋白质组和DMA)，以提供有关肺癌临床行为和治疗反应的详细信息；用于诊断和评估治疗反应的新的成像方法；以及新靶向治疗的开发。此外，动物，特别是小鼠肺癌模型的发展为系统了解和治疗肺癌提供了重要的新途径。已同意参加的发言者小组是这些领域的一些主要跨学科调查人员，他们积极寻求将他们的调查结果与诊所和实验室相互转化。

DESCRIPTION (provided by applicant): The aim of this proposal is to organize a scientific meeting entitled "Opportunities for Translation of the Molecular Pathogenesis of Lung Cancer to the Clinic", in San Diego, California from February 23 - 27, 2005. This AACR Special Conference brings together scientists and physicians that are leaders in the basic, translational, and clinical fields of lung cancer research. Lung cancer is the biggest cancer killer of men and women in the USA and in many countries around the world. This conference focuses on the many new important translational advances dealing with all aspects of lung cancer that promise a rationale approach to stopping this deadly disease. These include: understanding its molecular pathogenesis; genetic epidemiology; genetics of nicotine addiction and response to anti-smoking therapy; strategies for early detection including molecular detection; chemoprevention; molecular profiling (mRNA, proteomic, and DMA) of tumors and blood to provide detailed information on lung cancer clinical behavior and prediction of response to therapy; new imaging approaches for diagnosis and evaluation of therapeutic response; and the development of new targeted therapies. In addition, the development of animal, particularly mouse models of lung cancer provide an important new avenue to systematically understand and attack this disease. The group of speakers who have agreed to participate are some of the leading transdisciplinary investigators in these fields and are active in seeking to translate their findings to and from the clinic and the laboratory.