M. genitalium: behavioral and reproductive correlates

描述（由申请人提供）： 生殖支原体是一种性传播微生物，最近使用PCR技术从阴道和宫颈标本中鉴定出，患病率为3- 5%。这种微生物能够侵入上生殖道，因此可能是早产和其他妊娠并发症的原因。然而，M.生殖器在早产中的作用尚未得到系统评价。我们建议检查的行为，传染性和生殖相关的M。秘鲁利马的孕妇生殖器感染。我们的研究设计将利用正在进行的早产感染原因的病例对照研究。750例早产病例和750例对照病例将从利马一家大型三级转诊中心-产妇围产期研究所的分娩中选出。分娩后将获得宫颈拭子用于M。生殖器，以及沙眼衣原体和淋病奈瑟菌。我们还将评估阴道毛滴虫和细菌性阴道病。将通过标准化访谈收集人口统计学和行为信息。本研究有以下具体目的：1.目的探讨生殖支原体感染与其他性传播疾病及自发性早产的关系。2.探讨性生活史和行为特征作为M.生殖器感染和其他性传播疾病。本研究将主要在秘鲁利马与医学博士佩德罗·加西亚合作进行，作为NIH资助HD 41682的扩展。

DESCRIPTION (provided by applicant): Mycoplasma genitalium is a sexually transmitted microorganism recently identified from vaginal and cervical specimens using PCR technology, with a prevalence of 3-5%. This microbe is capable of invading the upper genital tract, and thus could plausibly be a cause of preterm birth and other pregnancy complications. However, the role of M. genitalium in preterm birth has not been systematically evaluated. We propose to examine the behavioral, infectious and reproductive correlates of M. genitalium infection among pregnant women in Lima, Peru. Our study design will take advantage of an on-going case-control study of infectious causes of preterm birth. 750 preterm cases and 750 controls will be selected from deliveries at the Instituto Materno Perinatal, a large tertiary referral center in Lima. Cervical swabs will be obtained after delivery for M. genitalium by PCR, as well as Chlamydia trachomatis and Neisseria gonorrhoeae. We will also evaluate vaginal Trichomonas and bacterial vaginosis. Demographic and behavioral information will be collected by standardized interview. The study has the following specific aims: 1. To examine the associations between M.genitalium infection and other STD with spontaneous preterm birth. 2. To examine sexual history and behavioral characteristics as risk factors for M. genitalium and other STD in pregnancy among Peruvian women. This research will be conducted primarily in Lima, Peru in collaboration with Pedro Garcia, MD, as an extension of NIH grant HD 41682.