M. genitalium: behavioral and reproductive correlates

生殖支原体：行为和生殖相关性

• 批准号: 6836564
• 负责人: JANE E HITTI
• 金额: $ 4.03万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6836564
• 关键词: African American; Lactobacillus; Mycoplasma genitalium; Peru; caucasian American; clinical research; disease /disorder proneness /risk; enzyme linked immunosorbent assay; female; genetic polymorphism; genetic susceptibility; human subject; hydrogen peroxide; inflammation; interview; polymerase chain reaction; pregnancy infection; premature labor; psychological stressor; reproductive system infection; sex behavior; sexually transmitted diseases; tumor necrosis factor alpha; western blottings; women' s health

DESCRIPTION (provided by applicant): Mycoplasma genitalium is a sexually transmitted microorganism recently identified from vaginal and cervical specimens using PCR technology, with a prevalence of 3-5%. This microbe is capable of invading the upper genital tract, and thus could plausibly be a cause of preterm birth and other pregnancy complications. However, the role of M. genitalium in preterm birth has not been systematically evaluated. We propose to examine the behavioral, infectious and reproductive correlates of M. genitalium infection among pregnant women in Lima, Peru. Our study design will take advantage of an on-going case-control study of infectious causes of preterm birth. 750 preterm cases and 750 controls will be selected from deliveries at the Instituto Materno Perinatal, a large tertiary referral center in Lima. Cervical swabs will be obtained after delivery for M. genitalium by PCR, as well as Chlamydia trachomatis and Neisseria gonorrhoeae. We will also evaluate vaginal Trichomonas and bacterial vaginosis. Demographic and behavioral information will be collected by standardized interview. The study has the following specific aims: 1. To examine the associations between M.genitalium infection and other STD with spontaneous preterm birth. 2. To examine sexual history and behavioral characteristics as risk factors for M. genitalium and other STD in pregnancy among Peruvian women. This research will be conducted primarily in Lima, Peru in collaboration with Pedro Garcia, MD, as an extension of NIH grant HD 41682.

描述（由申请人提供）：