MDMA Modulation of Sensory Information Processing

感觉信息处理的 MDMA 调制

• 批准号: 6936371
• 负责人: MELANIE L ALEXANDER
• 金额: $ 2.77万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-28 至 2007-03-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6936371
• 关键词: 3,4 methylenedioxymethamphetamine; biological signal transduction; brain stem; drug abuse; high performance liquid chromatography; laboratory rat; microdialysis; neural information processing; neurophysiology; neurotoxicology; neurotransmitter transport; norepinephrine; predoctoral investigator; sensory feedback; serotonin; single cell analysis; somesthetic sensory cortex; subthalamus

DESCRIPTION (provided by applicant): The specific aims of the proposed research is to define the effects of acute and chronic MDMA ('ecstasy') exposure on serotonin (5-HT) efflux and the functioning of sensory pathways in the mammalian brain using in vivo microdialysis and single unit recordings. The proposed experiments will use the well-defined rat trigeminal somatosensory system as a model to assess the effects of MDMA during acute and chronic exposure on the functioning of the somatosensory system. These experiments will test the hypothesis that acute and chronic MDMA results in alterations of 5-HT efflux and significant changes in the responsiveness of single sensory neurons to afferent information. Characterizing the acute and chronic effects of MDMA will contribute to our understanding of its popularity as a recreational drug. In addition, these experiments will lead to a better understanding of the physiological mechanisms underlying MDMA's effects on tactile information processing. Taken together, this will advance our knowledge of certain phenomena associated with MDMA administration including behavioral sensitization, tolerance, and drug relapse all of which involve sensory processes and contributes to MDMA's abuse liability.

描述（由申请人提供）： 拟议研究的具体目的是利用体内微透析和单单位记录来确定急性和慢性 MDMA（“摇头丸”）暴露对血清素（5-HT）流出以及哺乳动物大脑中感觉通路功能的影响。拟议的实验将使用明确的大鼠三叉神经体感系统作为模型来评估急性和慢性暴露期间 MDMA 对体感系统功能的影响。这些实验将检验以下假设：急性和慢性 MDMA 会导致 5-HT 流出的改变以及单个感觉神经元对传入信息的反应性的显着变化。描述 MDMA 的急性和慢性影响将有助于我们了解其作为娱乐性药物的流行程度。此外，这些实验将有助于更好地理解 MDMA 对触觉信息处理影响的生理机制。总而言之，这将增进我们对与 MDMA 管理相关的某些现象的了解，包括行为敏感性、耐受性和药物复发，所有这些都涉及感觉过程并导致 MDMA 的滥用倾向。