Mouse Models of Ovarian Cancer

卵巢癌小鼠模型

• 批准号: 6944831
• 负责人: ANNA M PUZIO
• 金额: $ 2.92万
• 依托单位: UNIV OF MED/DENT NJ-R W JOHNSON MED SCH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6944831
• 关键词: cell growth regulation; cell line; disease /disorder model; epithelium; female reproductive system neoplasm; gene induction /repression; gene targeting; genetically modified animals; homeobox genes; laboratory mouse; metastasis; model design /development; neoplasm /cancer genetics; oncogenes; ovary neoplasms; predoctoral investigator; tumor suppressor genes

DESCRIPTION (provided by applicant): Ovarian cancer is the leading cause of death from gynecological malignancies among females in the world. It is this fact and the lack of symptoms and reliable clinical markers in the early stages of the disease that make studying ovarian cancer so important. Several mouse models have been generated and have proven to be quite valuable in understanding the mechanisms that underlie neoplasmic transformation, progression and metastasis of various other human cancers. However, currently there are only a few mouse models of ovarian cancer available. The proposed research aims to develop a new generation of mouse models of ovarian cancer. I will establish an inducible system to delete tumor suppressor genes specifically in the surface epithelium of the ovary where human ovarian tumors are thought to arise. The generation of such a mouse model will provide insight into the genetic and molecular alterations that take place in ovarian cancer. Likewise, they will ultimately be highly beneficial to the identification of early diagnostic markers, prognostic markers, and other genetic changes that could potentially be used for human ovarian cancer studies.

描述（由申请方提供）：卵巢癌是全球女性妇科恶性肿瘤的主要死亡原因。正是这一事实，以及在疾病的早期阶段缺乏症状和可靠的临床标志物，使得研究卵巢癌变得如此重要。已经产生了几种小鼠模型，并且已经证明在理解各种其他人类癌症的肿瘤转化、进展和转移的机制方面是非常有价值的。然而，目前只有少数卵巢癌小鼠模型可用。这项研究旨在开发新一代卵巢癌小鼠模型。我将建立一个可诱导的系统，删除肿瘤抑制基因，特别是在卵巢表面上皮细胞，人类卵巢肿瘤被认为是产生。这种小鼠模型的产生将提供对卵巢癌中发生的遗传和分子改变的深入了解。同样，它们最终将非常有益于鉴定早期诊断标志物、预后标志物和其他可能用于人类卵巢癌研究的遗传变化。