Reconstructing and Interrupting the Epileptic Circuit Activity Using Electrical Impedance Tomography and Penetrating Depth Electrodes

使用电阻抗断层扫描和穿透深度电极重建和中断癫痫回路活动

• 批准号: 2578105
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2578105
• 关键词: Reconstructing; Interrupting; Epileptic; Circuit; Activity

1) Brief description of the context of the research including potential impactThe research project concerns imaging normal activity and clinical abnormalities in the brain such as stroke and epileptic seizures using the new medical imaging method of Electrical Impedance Tomography (EIT). This method comprises a box of electronics about the size of a hardback book and laptop and measurements are made typically using rings of ECG type electrodes. Over the past two decades, systems have been developed for imaging either fast electrical activity or else slower changes in the brain such as in stroke or epilepsy. These have been shown to work well in animal and tank studies but it has not yet been possible to translate this into hospital use. The idea of the project is to use EIT to image electrical activity in the brain in human subjects with epilepsy. This will advance understanding of how the brain codes information and assist in innovative treatments for epilepsy and psychiatric illness.2) Aims and Objectives -The specific objectives are to:1. Develop advanced signal processing methods and imaging algorithms2. Assist in the analysis of the data produced from epileptic patients' recordings.3) Novelty of Research Methodology: EIT can be a revolutionary advance for Epileptic seizures. EIT has 2 main advantages: The impedance is isotropic so it doesn't matter when the impedance changes, which way the dipole is facing, and the other advantage is that there is deep coverage of the location of epileptic activity when the electrode is placed on the skull. This could permit imaging of the ictal onset zone and so avoid the need for intracranial electrodes and their associated morbidity and complexity. Unlike the EEG, EIT can image deep into the head, so this would permit much more accurate diagnosis of epilepsy syndromes in an out-patient setting.4) Alignment to EPSRC's strategies and research areas: The project aligns with the EPSRC Healthcare technologies grand challenges. In particular, it involves "medical device design and innovation", "Disruptive technologies for sensing and analysis" cross-cutting capabilities, applied for "developing the future therapies" and "Frontiers of physical intervention"5) Any companies or collaborators involved: Cyqiq Ltd.

1）简要描述研究背景​​，包括潜在影响该研究项目涉及使用电阻抗断层扫描（EIT）这一新的医学成像方法对大脑中的正常活动和临床异常（例如中风和癫痫发作）进行成像。该方法包括一盒精装书和笔记本电脑大小的电子设备，通常使用心电图型电极环进行测量。在过去的二十年中，已经开发出用于对大脑中快速电活动或大脑中较慢变化（例如中风或癫痫）进行成像的系统。这些已被证明在动物和水箱研究中效果良好，但尚不可能将其转化为医院使用。该项目的想法是使用 EIT 对癫痫患者的大脑电活动进行成像。这将增进对大脑如何编码信息的理解，并有助于癫痫和精神疾病的创新治疗。2) 目的和目标 - 具体目标是：1。开发先进的信号处理方法和成像算法2。协助分析癫痫患者记录产生的数据。3) 研究方法的新颖性：EIT 可以成为癫痫发作的革命性进步。 EIT 有两个主要优点：阻抗是各向同性的，因此阻抗变化时、偶极子朝向哪个方向都无关紧要，另一个优点是当电极放置在头骨上时，可以深度覆盖癫痫活动的位置。这可以允许对发作区进行成像，从而避免对颅内电极的需要及其相关的发病率和复杂性。与 EEG 不同，EIT 可以深入头部成像，因此这将允许在门诊环境中更准确地诊断癫痫综合征。4) 与 EPSRC 的战略和研究领域保持一致：该项目与 EPSRC 医疗保健技术的重大挑战保持一致。特别是，它涉及“医疗器械设计和创新”、“传感和分析的颠覆性技术”跨领域能力，应用于“开发未来疗法”和“物理干预前沿”5) 涉及的任何公司或合作者：Cyqiq Ltd.