Modelling metabolic capability and phylogeny of host and environmental niche adaptation in E. coli

模拟大肠杆菌宿主的代谢能力和系统发育以及环境生态位适应

• 批准号: 2578240
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2578240
• 关键词: Modelling; metabolic; capability; phylogeny; host

The species Escherichia coli is a complex group of organisms which is found in a wide range of vertebrate animal hosts. The ability to colonise a given host is critical for E. coli and will require a different strategies, thus allowing for the evolution of separate lineages adapted to specific hosts. However, the high genetic diversity of E. coli means that detection of this niche adaptation is difficult. Given that there are multiple genotypic pathways to the same phenotypic endpoint, adaptation of E. coli to different host species may be more clearly observed by examination of phenotypes or metabolic pathways.This multidisciplinary project will define the variation in E. coli from different host species through genomic and phenotypic analysis. A new understanding of bacterial niche adaptation and novel computational tools will be developed.

大肠杆菌是一种复杂的生物群，广泛存在于脊椎动物宿主中。对大肠杆菌来说，在特定宿主上定植的能力至关重要，需要不同的策略，从而允许进化出适应特定宿主的单独谱系。然而，大肠杆菌的高遗传多样性意味着检测这种生态位适应是困难的。鉴于同一表型终点存在多种基因型途径，大肠杆菌对不同宿主物种的适应可能通过检查表型或代谢途径更清楚地观察到。这个多学科项目将通过基因组和表型分析确定不同宿主物种的大肠杆菌变异。对细菌生态位适应的新认识和新的计算工具将被开发。