Unravelling the relationship between RNA modification and RNA structure in RNA mobility

揭示RNA迁移中RNA修饰与RNA结构之间的关系

• 批准号: 2578674
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2578674
• 关键词: Unravelling; relationship; between; RNA; modification

RNA plays crucial roles in living cells, ranging from metabolite sensing, signalling, transcription, RNA processing to translation. Its function is determined by its sequence and structure. Structure can be perturbed by several factors, including modifications, a well-known example being methylation. RNA structure can thus encodes another layer of information besides the genetic code which can influence every step in the gene expression program as well as RNA signalling functions. Despite its key roles, we know very little about RNA structure and how it relates to function. This project aims to uncover the structure of mRNA using cutting-edge in vivo structure probing technologies coupled with advanced computational approaches, including deep learning.

RNA在活细胞中起着至关重要的作用，从代谢物传感，信号传导，转录，RNA加工到翻译。其功能由其序列和结构决定。结构可以被几个因素干扰，包括修饰，一个众所周知的例子是甲基化。因此，RNA结构可以编码除了遗传密码之外的另一层信息，这可以影响基因表达程序中的每一步以及RNA信号功能。尽管它的关键作用，我们对RNA结构及其与功能的关系知之甚少。该项目旨在使用尖端的体内结构探测技术结合先进的计算方法（包括深度学习）来揭示mRNA的结构。