Investigating the mechanisms of cell-surface receptor clustering in virus entry

研究病毒进入细胞表面受体聚集的机制

• 批准号: 2580891
• 金额: --
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2580891
• 关键词: Investigating; mechanisms; cell; surface; receptor

This PhD project will focus on developing novel simulations of receptor clustering in cell membranes. To infect a cell, viruses must penetrate cellular membrane barriers. Viruses engage specific receptors that typically cluster on the cell-surface upon virus binding, facilitating the molecular interactions that lead to penetration. Receptor clustering is known to influence the entry of viruses into cells, and so this research will have broad applicability to virus infection.

这个博士项目将专注于开发细胞膜中受体聚集的新模拟。要感染细胞，病毒必须穿透细胞膜屏障。病毒与特定受体结合，这些受体通常在病毒结合后聚集在细胞表面，促进导致渗透的分子相互作用。已知受体聚集会影响病毒进入细胞，因此这项研究将对病毒感染具有广泛的适用性。