Chiral Approaches to Natural Product Synthesis

描述：（由申请人提供）该计划的长期目标 包括实验室合成复杂的天然产物， 所需的生物活性以及新的合成 这种方法可以简化这项任务。此外，我们计划尝试 鉴定、合成和测试这些天然存在铅的类似物 这些化合物可以以比合成更实用的方式获得， 天然化合物本身。正在进行的全合成研究 将继续使用复方细胞毒性大环十二烷苷， 有望完成对这种有前途的化合物的研究 埃坡霉素，其活性与紫杉醇相似。我们的研究 有效的和非常有前途的抗癌剂苔藓抑素1将继续， 我们希望将这个计划积极地扩展到模拟合成。的合成 将开始使用亮白Candrolide和多拉倍利特B， 将制备无色Candrolide用于作为抗真菌剂和细胞毒性剂的测定。 在所有这些工作中，我们希望实现新的有机反应， 综合战略，这将有助于建设有针对性的 化合物，以及证明在更广泛的背景下有用。

DESCRIPTION: (provided by applicant) The long term goals of this program include the laboratory synthesis of complex natural products possessing desirable biological activity as well as the development of new synthetic methodology that will simplify this task. In addition, we plan to attempt to identify, and to synthesize and test, analogs of these naturally occurring lead compounds which can be accessed synthetically in a more practical manner than the natural compounds themselves. Ongoing investigations on the total synthesis of the complex cytotoxic macrodiolide swinholide will be continued and hopefully brought to completion, as will studies on the promising compound epothilone, which has activity similar to that of taxol. Our studies on the potent and extremely promising anticancer agent bryostatin 1 will continue, and we hope to expand this program aggressively into analog synthesis. Syntheses of leucascandrolide and dolabelide B will be initiated, and analogs of leucascandrolide will be prepared for assay as antifungal and cytotoxic agents. Throughout all of this work, we hope to implement new organic reactions and synthetic strategies which will facilitate the construction of the targeted compounds, as well as prove useful in a broader context.