CHIRAL APPROACHES TO NATURAL PRODUCT SYNTHESIS

拟议的研究涉及研究和开发一种 各种碳-碳键形成反应， 特别适用于合成天然的 具有所需抗生素或抗肿瘤活性的产品，和 这些方法在全合成此类化合物中的应用 化合物. 具体实例包括抗生素，例如 Colletodiol、卡西霉素、卡波霉素和泰乐菌素，以及 抗肿瘤剂除莠霉素。 本文综合考察了 非常有前途的根霉素家族的抗肿瘤剂，设计不 不仅最终成功地进行了实验室合成，而且还 揭示活动所需的结构特征，并提供 更简单的生物活性类似物，也被提出作为一种 举例说明这种方法如何允许特别简明 生物重要化合物的合成。

The proposed research involves the study and development of a variety of carbon-carbon bond forming reactions which are particularly well suited for use in the synthesis of natural products possessing desirable antibiotic or antitumor activity, and the application of these methods to total syntheses of such compounds. Specific examples include antibiotics such as colletodiol, calcimycin, carbomycin and tylosin, as well as the antitumor agent herbimycin. A synthetic investigation of the very promising rhizoxin family of antitumor agents, designed not only to culminate in a successful laboratory synthesis but also to reveal structural features required for activity and to provide simpler biologically active analogues, is also proposed as an example of how such methodology allows for particularly concise syntheses of biologically important compounds.