Development of combined bio- and chemo-catalytic cascades for the preparation active pharmaceutical ingredients (APIs)

开发用于制备活性药物成分（API）的组合生物和化学催化级联

• 批准号: 2583111
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2583111
• 关键词: Development; combined; bio; chemo; catalytic

This project will source natural enzymes from metabolic pathways and where necessary, evolve them to expand their substrate scope. We will combine these biocatalysts with compatible chemo-catalysts to expand the synthetic utility of the optimised route. This project will provide training in modern biocatalyst methodology and analysis (recombinant DNA technology, enzyme characterisation and engineering). We will aim to collaborate with experts in x-ray crystallography to guide engineering/evolution of target enzymes. Moreover, the Campopiano labs have built an extensive network of links with industrial biocatalysis teams and there will be an opportunity to expand our collaborations with them

该项目将从代谢途径中获取天然酶，并在必要时对其进行进化以扩大其底物范围。我们将把这些生物催化剂与兼容的化学催化剂结合起来，以扩大优化路线的合成效用。该项目将提供现代生物催化剂方法和分析（重组 DNA 技术、酶表征和工程）方面的培训。我们的目标是与 X 射线晶体学专家合作，指导目标酶的工程/进化。此外，坎皮亚诺实验室与工业生物催化团队建立了广泛的联系网络，我们将有机会扩大与他们的合作