OCT-Guided Interventions for Pain Management

OCT 引导的疼痛管理干预措施

• 批准号: 6920632
• 负责人: Cha-Min Tang
• 金额: $ 25.56万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6920632
• 关键词: analgesia; bioengineering /biomedical engineering; bioimaging /biomedical imaging; catheterization; chronic pain; dogs; epidural anesthesia; human tissue; musculoskeletal imaging /visualization /scanning; obstetric anesthesia; optical tomography; postmortem; radiodiagnosis; spine; technology /technique development

DESCRIPTION (provided by applicant): The spinal epidural space is a poorly accessible site within the bony spinal canal where therapeutic interventions that affect millions of Americans are carried out each year. Examples include epidural anesthesia and management of low back pain. Between two and three million epidurals are performed each year in this country for obstetrical analgesia. A comparable number of epidural anesthesia procedures are performed as part of other surgical indications. Low back pain has been estimated to exact >$50 billion a year burden on the American economy. The pathology typically lies within or immediately adjacent to the epidural space. Existing clinical imaging technology is unable to provide the spatial resolution or the realtime capabilities needed for therapeutic interventions within this space. There is a great unfilled need to be able to clearly image in real-time structures such as individual nerve roots, blood vessels, dura, free disc fragments, and fibrous scar tissue within and adjacent to the spinal epidural space. Optical coherence tomography (OCT) is an emerging technology that is ideally and uniquely suited for imaging within the spinal canal. The first goal of this project is to modifiy and adapt catheter-based OCT technology for applications in the spine. The second goal is to determine the feasibility and advantages of OCT-guided interventions for acute and chronic pain management. This will be a collaborative effort between an academic medical center and the industry leader in catheter-based OCT technology.

描述（由申请人提供）： 椎管内硬膜外腔是骨性椎管内难以接近的部位，每年都会在这里进行影响数百万美国人的治疗干预。例子包括硬膜外麻醉和腰痛治疗。该国每年进行两到三百万例硬膜外麻醉用于产科镇痛。作为其他手术适应症的一部分，进行了相当数量的硬膜外麻醉手术。据估计，腰痛每年给美国经济造成超过 500 亿美元的负担。病变通常位于硬膜外腔内或紧邻硬膜外腔。现有的临床成像技术无法提供该空间内治疗干预所需的空间分辨率或实时功能。对于能够对脊髓硬膜外腔内和邻近的单个神经根、血管、硬脑膜、游离椎间盘碎片和纤维疤痕组织等实时结构进行清晰成像存在着巨大的未满足的需求。光学相干断层扫描 (OCT) 是一项新兴技术，非常适合椎管内成像。该项目的首要目标是修改和调整基于导管的 OCT 技术以应用于脊柱。第二个目标是确定 OCT 引导的急性和慢性疼痛管理干预措施的可行性和优势。这将是学术医疗中心和基于导管的 OCT 技术行业领导者之间的合作成果。