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METHOD TO PROBE POSTSYNAPTIC MODIFICATIONS IN PLASTICITY

METHOD TO PROBE POSTSYNAPTIC MODIFICATIONS IN PLASTICITY
探测可塑性突触后变化的方法
批准号：
2891109
负责人：
Cha-Min Tang
金额：
$7.43万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-07-01 至 2000-06-30
来源：
https://reporter.nih.gov/project-details/2891109
关键词：
bioimaging /biomedical imaging drug delivery systems fiber optics glutamate receptor glutamates hippocampus laboratory rat lasers method development neural plasticity neurotransmitters photolysis receptor sensitivity synapses tissue /cell preparation

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英文摘要
DESCRIPTION (Adapted from applicant's abstract): This 'small grant' seeks to develop a method to apply neurotransmitters rapidly and focally in brain slice preparations in such a manner as to activate individual dendritic spines directly. Such a method could be used to distinguish presynaptic from postsynaptic actions in studies of synaptic plasticity, to map the distribution of glutamate receptors, and to study dendritic excitability. We have developed a method for light-induced release of glutamate from caged compounds under tissue culture conditions. This method relies on single-mode optical fibers to achieve saturating concentrations of glutamate within a 3 pm Spot in less than 1 ms. We now seek to apply this methodology to the brain slice preparation.
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