Dietary Protein Effect on Bone Mass, Loss and Fracture

描述（由申请人提供）：近3000万美国人患有骨质疏松症，每年发生超过180万例骨质疏松性骨折，随着美国人口老龄化，这些数字将显著增加。众所周知，营养摄入会影响骨骼，这是一个潜在的可改变因素。传统上，钙和维生素D一直是大多数关于骨骼健康的营养研究的焦点。因此，人们对膳食蛋白质对骨骼健康的作用知之甚少。我们建议从不同的骨骼部位检查膳食蛋白质和年龄相关的骨质流失。饮食因素在骨质疏松症中是一个重要的未被充分研究的领域，这项工作将使我们更好地了解保护骨骼的方法，并深入了解蛋白质影响骨矿物质密度（BMD）的可能机制。本研究旨在对以人群为基础的Framingham队列进行8-13年的随访，研究膳食蛋白质与骨量、髋部和脊柱纵向骨质流失、跌倒和髋部骨折之间的关系。具体来说，本研究通过一个特征明确的队列，通过以下4个具体目标来研究膳食蛋白质摄入与骨骼健康之间的可能途径：1)骨密度，2)骨质流失，3)瘦质量和跌倒，4)髋部骨折。弗雷明汉研究收集的丰富数据也将使我们能够检查饮食蛋白质摄入和骨骼健康之间可能存在的其他因素。该项目将广泛使用从以前的弗雷明汉基金中收集的资源和数据。因此，通过利用这些数据资源，我们提出的研究将能够以更低的成本实现其目标，并将营养对骨骼影响的研究扩展到以前未探索的重要新领域。

DESCRIPTION (provided by applicant): Almost 30 million Americans are affected by osteoporosis with over 1.8 million osteoporotic fractures occurring each year, and these figures will increase significantly as the American population ages. Nutritional intake is known to affect bone and is a potentially modifiable factor. Traditionally, calcium and vitamin D have been the focus in most nutrition studies addressing bone health. As such, relatively little is known about the role of dietary protein on skeletal health. We propose to examine dietary protein and age- related bone loss from different skeletal sites. Dietary factors represent an important understudied area in osteoporosis and this work will allow us to better understanding ways to preserve bone as well as insights into the possible mechanisms for a protein influence on bone mineral density (BMD). This study proposes to examine associations between dietary protein and bone mass, longitudinal bone loss of the hip and spine, falls and hip fracture over 8-13 year follow-up among the population-based Framingham Cohort. Specifically, using a well-characterized cohort, the 4 specific aims of this study will examine the possible pathway between dietary protein intakes and skeletal health via: 1) BMD, 2) bone loss, 3) lean mass and falls, and 4) hip fracture. The richness of the data collected by the Framingham Study will also permit us to examine other factors that may be on the pathway between dietary protein intake and bone health. This project will make extensive use of the resources and data already collected from previous Framingham grants. Thus, by leveraging these data resources, our proposed study will be able to achieve its goals at lower cost, and extend the investigation of nutritional influences upon bone into important new areas that were previously unexplored. The proposed study will provide essential information on associations of keen interest both to clinical medicine and public health. Better understanding of potentially modifiable factors such as dietary protein may help us make more reliable public health interventions targeted at preserving bone. Bone loss and osteoporosis are serious burdens for many older individuals. This study will provide insights on potential mechanisms to reduce osteoporotic risks. Based on strong preliminary data, this study will provide new and important information about the role of dietary protein upon bone outcomes in older men and women. Dietary factors are poorly understood, yet potentially modifiable. More information is needed on the precise effects of dietary protein on bone health for community-based men and women.