Dietary Protein Effect on Bone Mass, Loss and Fracture

膳食蛋白质对骨量、骨损失和骨折的影响

• 批准号: 7018247
• 负责人: Marian T. Hannan
• 金额: $ 27.37万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7018247
• 关键词: accidental falls; bone density; bone fracture; clinical research; dietary proteins; hip fractures; human data; longitudinal human study; nutrition related tag; osteoporosis; pathologic bone resorption; spine

DESCRIPTION (provided by applicant): Almost 30 million Americans are affected by osteoporosis with over 1.8 million osteoporotic fractures occurring each year, and these figures will increase significantly as the American population ages. Nutritional intake is known to affect bone and is a potentially modifiable factor. Traditionally, calcium and vitamin D have been the focus in most nutrition studies addressing bone health. As such, relatively little is known about the role of dietary protein on skeletal health. We propose to examine dietary protein and age- related bone loss from different skeletal sites. Dietary factors represent an important understudied area in osteoporosis and this work will allow us to better understanding ways to preserve bone as well as insights into the possible mechanisms for a protein influence on bone mineral density (BMD). This study proposes to examine associations between dietary protein and bone mass, longitudinal bone loss of the hip and spine, falls and hip fracture over 8-13 year follow-up among the population-based Framingham Cohort. Specifically, using a well-characterized cohort, the 4 specific aims of this study will examine the possible pathway between dietary protein intakes and skeletal health via: 1) BMD, 2) bone loss, 3) lean mass and falls, and 4) hip fracture. The richness of the data collected by the Framingham Study will also permit us to examine other factors that may be on the pathway between dietary protein intake and bone health. This project will make extensive use of the resources and data already collected from previous Framingham grants. Thus, by leveraging these data resources, our proposed study will be able to achieve its goals at lower cost, and extend the investigation of nutritional influences upon bone into important new areas that were previously unexplored. The proposed study will provide essential information on associations of keen interest both to clinical medicine and public health. Better understanding of potentially modifiable factors such as dietary protein may help us make more reliable public health interventions targeted at preserving bone. Bone loss and osteoporosis are serious burdens for many older individuals. This study will provide insights on potential mechanisms to reduce osteoporotic risks. Based on strong preliminary data, this study will provide new and important information about the role of dietary protein upon bone outcomes in older men and women. Dietary factors are poorly understood, yet potentially modifiable. More information is needed on the precise effects of dietary protein on bone health for community-based men and women.

描述（申请人提供）：近 3000 万美国人受到骨质疏松症的影响，每年发生超过 180 万例骨质疏松性骨折，并且随着美国人口老龄化，这些数字将显着增加。众所周知，营养摄入会影响骨骼，并且是一个潜在的可改变因素。传统上，钙和维生素 D 一直是大多数骨骼健康营养研究的焦点。因此，人们对膳食蛋白质对骨骼健康的作用知之甚少。我们建议检查膳食蛋白质和不同骨骼部位与年龄相关的骨质流失。饮食因素是骨质疏松症中一个重要的待研究领域，这项工作将使我们能够更好地了解保护骨骼的方法，并深入了解蛋白质影响骨矿物质密度 (BMD) 的可能机制。本研究旨在对基于人群的弗雷明汉队列进行 8-13 年随访，研究膳食蛋白质与骨量、髋部和脊柱的纵向骨质流失、跌倒和髋部骨折之间的关联。具体来说，本研究的 4 个具体目标将使用一个特征明确的队列，通过以下方式检查膳食蛋白质摄入量和骨骼健康之间的可能途径：1) BMD，2) 骨质流失，3) 瘦体重和跌倒，以及 4) 髋部骨折。弗雷明汉研究收集的丰富数据也将使我们能够研究可能影响膳食蛋白质摄入和骨骼健康之间关系的其他因素。该项目将广泛利用从弗雷明汉之前的资助中收集的资源和数据。因此，通过利用这些数据资源，我们提出的研究将能够以较低的成本实现其目标，并将营养对骨骼影响的研究扩展到以前未探索的重要新领域。 拟议的研究将提供与临床医学和公共卫生密切相关的协会的重要信息。更好地了解膳食蛋白质等潜在可改变因素可能有助于我们制定更可靠的旨在保护骨骼的公共卫生干预措施。骨质流失和骨质疏松症对许多老年人来说是严重的负担。这项研究将为降低骨质疏松风险的潜在机制提供见解。基于强有力的初步数据，这项研究将提供有关膳食蛋白质对老年男性和女性骨骼结果的作用的新的重要信息。人们对饮食因素知之甚少，但可能是可以改变的。需要更多关于膳食蛋白质对社区男性和女性骨骼健康的确切影响的信息。