Dietary Protein Effect on Bone Mass, Loss and Fracture

膳食蛋白质对骨量、骨损失和骨折的影响

• 批准号: 7018247
• 负责人: Marian T. Hannan
• 金额: $ 27.37万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7018247
• 关键词: accidental falls; bone density; bone fracture; clinical research; dietary proteins; hip fractures; human data; longitudinal human study; nutrition related tag; osteoporosis; pathologic bone resorption; spine

DESCRIPTION (provided by applicant): Almost 30 million Americans are affected by osteoporosis with over 1.8 million osteoporotic fractures occurring each year, and these figures will increase significantly as the American population ages. Nutritional intake is known to affect bone and is a potentially modifiable factor. Traditionally, calcium and vitamin D have been the focus in most nutrition studies addressing bone health. As such, relatively little is known about the role of dietary protein on skeletal health. We propose to examine dietary protein and age- related bone loss from different skeletal sites. Dietary factors represent an important understudied area in osteoporosis and this work will allow us to better understanding ways to preserve bone as well as insights into the possible mechanisms for a protein influence on bone mineral density (BMD). This study proposes to examine associations between dietary protein and bone mass, longitudinal bone loss of the hip and spine, falls and hip fracture over 8-13 year follow-up among the population-based Framingham Cohort. Specifically, using a well-characterized cohort, the 4 specific aims of this study will examine the possible pathway between dietary protein intakes and skeletal health via: 1) BMD, 2) bone loss, 3) lean mass and falls, and 4) hip fracture. The richness of the data collected by the Framingham Study will also permit us to examine other factors that may be on the pathway between dietary protein intake and bone health. This project will make extensive use of the resources and data already collected from previous Framingham grants. Thus, by leveraging these data resources, our proposed study will be able to achieve its goals at lower cost, and extend the investigation of nutritional influences upon bone into important new areas that were previously unexplored. The proposed study will provide essential information on associations of keen interest both to clinical medicine and public health. Better understanding of potentially modifiable factors such as dietary protein may help us make more reliable public health interventions targeted at preserving bone. Bone loss and osteoporosis are serious burdens for many older individuals. This study will provide insights on potential mechanisms to reduce osteoporotic risks. Based on strong preliminary data, this study will provide new and important information about the role of dietary protein upon bone outcomes in older men and women. Dietary factors are poorly understood, yet potentially modifiable. More information is needed on the precise effects of dietary protein on bone health for community-based men and women.

描述(申请人提供)：近3000万美国人患有骨质疏松症，每年发生的骨质疏松性骨折超过180万例，随着美国人口老龄化，这些数字将显著增加。众所周知，营养摄入会影响骨骼，是一个潜在的可修改因素。传统上，钙和维生素D一直是大多数针对骨骼健康的营养研究的重点。因此，人们对饮食蛋白质对骨骼健康的作用知之甚少。我们建议检查不同骨骼部位的膳食蛋白质和与年龄相关的骨丢失。饮食因素是骨质疏松症中一个重要的未被研究的领域，这项工作将使我们更好地了解保存骨骼的方法，以及深入了解蛋白质影响骨密度(BMD)的可能机制。这项研究建议在以人口为基础的Framingham队列中检查饮食蛋白质与骨量、髋部和脊柱的纵向骨丢失、跌倒和髋部骨折之间的关系，时间为8-13年。具体地说，利用一个特征明确的队列，这项研究的4个具体目标将检查饮食蛋白质摄入量和骨骼健康之间的可能途径：1)骨密度，2)骨丢失，3)瘦体重和跌倒，以及4)髋部骨折。弗雷明汉研究收集的丰富数据还将使我们能够检查饮食蛋白质摄入量和骨骼健康之间可能存在的其他因素。该项目将广泛利用已从以前的弗雷明翰赠款收集的资源和数据。因此，通过利用这些数据资源，我们提议的研究将能够以较低的成本实现其目标，并将营养对骨骼影响的调查扩展到以前未探索的重要新领域。 这项拟议的研究将提供与临床医学和公共卫生密切相关的重要信息。更好地了解潜在的可修改因素，如饮食蛋白质，可能有助于我们制定更可靠的公共卫生干预措施，以保护骨骼。骨质流失和骨质疏松症是许多老年人的严重负担。这项研究将为降低骨质疏松症风险的潜在机制提供见解。基于强有力的初步数据，这项研究将提供有关饮食蛋白质对老年男性和女性骨骼结果的作用的新的重要信息。人们对饮食因素知之甚少，但可能是可以改变的。需要更多关于饮食蛋白质对社区男性和女性骨骼健康的确切影响的信息。