Metabolic Consequences of Low & High Carbohydrate Diets

低代谢的后果

• 批准号: 6947864
• 负责人: NJERI KARANJA
• 金额: $ 65.64万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6947864
• 关键词: adult human (21+); behavioral /social science research tag; bioenergetics; body composition; bone density; cardiovascular disorder risk; clinical research; clinical trials; diet therapy; dietary carbohydrates; disease /disorder proneness /risk; human subject; human therapy evaluation; hunger; kidney disorder; kidney function; metabolism; nutrition related tag; obesity; osteoporosis; patient oriented research; satiations; weight control

DESCRIPTION (provided by applicant): There is an epidemic of obesity in the United States which is accompanied by the populace's effort to lose weight. Low-carbohydrate diets are a popular alternative to traditional dietary approaches to weight loss. These diets may result in short-term weight loss and the improvement in disease risk normally seen with weight loss, but their effects on long-term weight loss and disease risk are unknown. We propose a randomized, controlled trial to systematically assess health claims about low-carbohydrate diets, and explore concerns expressed about these diets by health professionals. We will compare the short- and long-term effects of the Atkins diet (low-carbohydrate) and the Dietary Approaches to Stop Hypertension (DASH) diet (high-carbohydrate) on weight loss, body composition, physiological markers of energy and weight regulation, markers of cardiovascular disease (CVD), bone health, and renal function. The study blends applied behavioral research with basic mechanistic research to clarify the interaction between the behavior and biology of weight and energy regulation. We will recruit and enroll overweight and obese adults who wish to lose weight, and who agree to be randomized to either the DASH or the Atkins diet for the duration of the study. The randomized population will include 240 participants, 60percent of whom will be women and 20percent of whom will be ethnic and racial minorities so that our outcomes can be generalized to the US population. In Phase I, study subjects will participate in an intensive 6-month behavioral intervention program designed to facilitate weight loss. This will be followed by a maintenance phase (Phase II) in which counselors provide support to participants to maintain weight loss for 2 years. The primary outcome is a change in weight between the beginning of the study and the end of 30 months of follow-up.

描述（由申请人提供）：美国有一种肥胖症流行，伴随着民众减肥的努力。低碳水化合物饮食是传统饮食减肥方法的流行替代品。这些饮食可能会导致短期体重减轻以及通常会因体重减轻而发现的疾病风险的改善，但它们对长期体重减轻和疾病风险的影响尚不清楚。我们提出了一项随机，对照试验，以系统地评估对低碳水化合物饮食的健康主张，并探讨卫生专业人员对这些饮食表达的担忧。我们将比较Atkins饮食（低碳水化合物）的短期和长期影响以及饮食中停止高血压（DASH）饮食（高碳水化合物）对体重减轻，身体组成，能量和体重调节的生理标记，心血管疾病（CVD），骨骼健康和肾功能的方法。该研究将应用行为研究与基本机械研究融合在一起，以阐明体重和能量调节的行为与生物学之间的相互作用。在研究期间，我们将招募和招募希望减肥的超重成年人，并同意在研究期间随机分配仪表板或阿特金斯饮食。随机人群将包括240名参与者，其中60％将是妇女，其中20％将是种族和种族少数群体，以便我们的成果可以推广到美国人口。在第一阶段，研究对象将参加旨在促进体重减轻的密集的6个月行为干预计划。随后将是维护阶段（第二阶段），在该阶段中，辅导员为参与者提供了2年的体重减轻的支持。主要结果是研究开始与随访30个月结束之间的重量变化。