Research Training in Alimentary Tract Surgery

消化道外科研究培训

• 批准号: 7092910
• 负责人: DAVID I SOYBEL
• 金额: $ 5.19万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-18 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7092910
• 关键词: Research; Training; Alimentary; Tract; Surgery

EXCEED THE SPACE PROVIDED. This Program provides research training for young surgeons who plan careers for patient care and investigation in surgical problems of the alimentary tract. Its primary purpose is to prepare these individuals to become independently funded investigators. The program provides intensive, coordinated research training in fundamental aspects of molecular and cell biology, biochemistry and biophysics, organ physiology and pathophysiology, and immunology, as they apply to diseases of the alimentary tract, hepatobiliary system and pancreas. First funded in 1997 as a collaboration between the Departments of Surgery at the Brigham and Women's Hospital and the former Beth Israel Hospital, this program is now expanded to include NIH-funded surgical research laboratories at all major adult teaching hospital affiliates of Harvard Medical School. Current areas of investigation by core preceptor group include: 1) gastro-intestinal mucosal secretion and barrier function (Soybel, Hofer, Hagen); 2) energetics and metabolic derangements of liver in sepsis and shock (Fischer, Hasselgren); 3) gut differentiation and growth responses to starvation or massive resection (Hodin, Ashley, Zinner); 4) cell biology and pathophysiology of acute and chronic pancreatitis (Warshaw); 5) molecular basis of pancreatic cancer growth and metastasis (Callery); 6) tissue engineering as applied to reconstruction and rehabilitation of the alimentary tract (Vacanti, Whang); and 7) evaluation of outcomes and introduction of new technologies in operations on the Digestive System (Zinner, Warshaw, Daley). In addition, a number of young faculty have been recruited to the different Departments of Surgery at HMS, with intention of their development as surgeon-investigators in the field of GI and HPB Surgery. We propose to include these young faculty, under clearly specified circumstances, as co- mentors of our research fellows, thereby enhancing the environment for learning and providing an environment of mentoring for future mentors. The program will be enriched by opportunties for formal coursework in basic sciences and experimental techniques at Harvard's Medical School and School of Public Health, by interactions with core labs and investigators of the NIH-funded Digestive Diseases Centers (HMS-based and MGH-based), and by participation in clinical and research conferences offered at each institution. The training Program Executive Committee (Soybel, Hodin, Hasselgren) oversees selection of trainees, designation of precptors, prescription of formal coursework, and participation of trainees in programs teaching ethics and responsible conduct in research. Trainees are selected through a process open to surgical residents or fellows in accredited U.S. Surgical Residency Training Programs. A pro-active process for seeking applications from individuals belonging to under-represented minority groups is coordinated through the Offices for Diversity at HMS and each of the participating institutions. PERFORMANCE SITE ========================================Section End===========================================

超出所提供的空间。该计划为年轻外科医生提供研究培训，这些医生计划从事病人护理和消化道外科问题调查。其主要目的是培养这些人成为独立资助的调查人员。该计划在分子和细胞生物学，生物化学和生物物理学，器官生理学和病理生理学以及免疫学的基本方面提供密集，协调的研究培训，因为它们适用于消化道，肝胆系统和胰腺疾病。1997年，作为布里格姆妇女医院和前贝斯以色列医院外科部门之间的合作，该计划首次获得资助，现在已扩大到包括哈佛医学院所有主要成人教学医院附属机构的NIH资助的外科研究实验室。核心导师组目前的研究领域包括：1）胃肠道粘膜分泌和屏障功能（Jumbel，霍费尔，哈根）; 2）脓毒症和休克时肝脏的能量学和代谢紊乱（Fischer，Hasselgren）; 3）肠道分化和生长对饥饿或大规模切除的反应（Hodin，阿什利，Zinner）; 4）急性和慢性胰腺炎的细胞生物学和病理生理学（Warshaw）; 5）胰腺癌生长和转移的分子基础（Callery）; 6）组织工程学应用于消化道的重建和康复（Vacanti，Whang）;和7）消化系统手术的结果评估和新技术的引入（Zinner，Warshaw，Daley）。此外，一些年轻的教师已被招募到HMS的不同外科部门，他们的发展作为GI和HPB手术领域的外科医生调查员的意图。我们建议在明确指定的情况下，让这些年轻的教师成为我们研究人员的共同导师，从而改善学习环境，并为未来的导师提供指导环境。该计划将通过哈佛医学院和公共卫生学院的基础科学和实验技术的正式课程，与NIH资助的消化疾病中心（基于HMS和基于MGH）的核心实验室和研究人员的互动，以及参与每个机构提供的临床和研究会议来丰富。培训计划执行委员会（Bibel，Hodin，Hasselgren）监督学员的选择，指定导师，正式课程的规定，以及学员参与教授道德和负责任的研究行为的计划。受训人员是通过一个过程中开放给外科住院医生或研究员在认可的美国外科住院医生培训计划选择。通过HMS的多样性办公室和每个参与机构协调一个积极主动的程序，寻求属于代表性不足的少数群体的个人的申请。性能现场=