Research Training in Alimentary Tract Surgery

该计划为年轻的外科医生提供研究培训，他们计划从事病人护理和调查， 消化道的外科问题。它的主要目的是准备这些人成为 独立资助的调查员。该计划提供了密集的，协调的基础研究培训 分子和细胞生物学、生物化学和生物物理学、器官生理学和病理生理学方面，以及 免疫学，因为它们适用于消化道，肝胆系统和胰腺疾病。首次资助于 1997年，布里格姆妇女医院外科部门与 前贝斯以色列医院，该计划现在扩大到包括NIH资助的外科研究实验室， 所有哈佛医学院附属成人教学医院。按核心分列的当前调查领域 导师组包括：1）胃肠道粘膜分泌和屏障功能（Rumebel，霍费尔，哈根）; 2） 脓毒症和休克时肝脏的能量学和代谢紊乱（Fischer，Hasselgren）; 3）肠道分化 和对饥饿或大规模切除的生长反应（Hodin，阿什利，Zinner）; 4）细胞生物学和 急性和慢性胰腺炎的病理生理学（Warshaw）; 5）胰腺癌生长的分子基础， 转移（Callery）; 6）应用于消化道重建和康复的组织工程 （Vacanti，Whang）; 7）评估成果并在业务中引入新技术， 消化系统（Zinner，Warshaw，Daley）。此外，还招聘了一些年轻的教员， HMS的不同外科部门，旨在将他们发展为该领域的外科医生调查员 胃肠道和腹主动脉瘤手术我们建议在明确规定的情况下，将这些年轻的教师包括在内，作为共同- 我们的研究人员的导师，从而提高学习的环境，并提供一个环境， 为未来的导师提供指导。该计划将通过基础课程的正式课程机会来丰富 科学和实验技术在哈佛医学院和公共卫生学院，通过互动 与NIH资助的消化疾病中心（基于HMS和基于MGH）的核心实验室和研究人员一起， 以及参加每个机构提供的临床和研究会议。培训计划 执行委员会（Bibel，Hodin，Hasselgren）监督学员的选择，导师的指定， 正式课程的规定，以及受训人员参与道德和责任教育方案 进行研究。受训者是通过一个过程中开放给外科住院医生或研究员在认可的选择 美国外科住院医师培训计划。积极主动地征求个人申请 属于代表性不足的少数群体的人通过HMS的多样性办公室进行协调， 的参与机构。

This Program provides research training for young surgeons who plan careers for patient care and investigation in surgical problems of the alimentary tract. Its primary purpose is to prepare these individuals to become independently funded investigators. The program provides intensive, coordinated research training in fundamental aspects of molecular and cell biology, biochemistry and biophysics, organ physiology and pathophysiology, and immunology, as they apply to diseases of the alimentary tract, hepatobiliary system and pancreas. First funded in 1997 as a collaboration between the Departments of Surgery at the Brigham and Women's Hospital and the former Beth Israel Hospital, this program is now expanded to include NIH-funded surgical research laboratories at all major adult teaching hospital affiliates of Harvard Medical School. Current areas of investigation by core preceptor group include: 1) gastro-intestinal mucosal secretion and barrier function (Soybel, Hofer, Hagen); 2) energetics and metabolic derangements of liver in sepsis and shock (Fischer, Hasselgren); 3) gut differentiation and growth responses to starvation or massive resection (Hodin, Ashley, Zinner); 4) cell biology and pathophysiology of acute and chronic pancreatitis (Warshaw); 5) molecular basis of pancreatic cancer growth and metastasis (Callery); 6) tissue engineering as applied to reconstruction and rehabilitation of the alimentary tract (Vacanti, Whang); and 7) evaluation of outcomes and introduction of new technologies in operations on the Digestive System (Zinner, Warshaw, Daley). In addition, a number of young faculty have been recruited to the different Departments of Surgery at HMS, with intention of their development as surgeon-investigators in the field of GI and HPB Surgery. We propose to include these young faculty, under clearly specified circumstances, as co- mentors of our research fellows, thereby enhancing the environment for learning and providing an environment of mentoring for future mentors. The program will be enriched by opportunties for formal coursework in basic sciences and experimental techniques at Harvard's Medical School and School of Public Health, by interactions with core labs and investigators of the NIH-funded Digestive Diseases Centers (HMS-based and MGH-based), and by participation in clinical and research conferences offered at each institution. The training Program Executive Committee (Soybel, Hodin, Hasselgren) oversees selection of trainees, designation of precptors, prescription of formal coursework, and participation of trainees in programs teaching ethics and responsible conduct in research. Trainees are selected through a process open to surgical residents or fellows in accredited U.S. Surgical Residency Training Programs. A pro-active process for seeking applications from individuals belonging to under-represented minority groups is coordinated through the Offices for Diversity at HMS and each of the participating institutions.