UT Gastroenterology/Hepatology Research Training Program

BB首席研究员/项目主任（后、中、前）：DIETSCHY。约翰·莫里斯描述。说明应用程序的广泛、长期目标和具体目的，并参考项目与健康的关系。简要描述了本文的研究设计和实现方法。避免总结过去的成就和用第一人称说话。此描述旨在简洁而准确地描述^^当与应用程序分离时的建议工作^^fc如果应用程序得到资助，此描述将成为公共信息。因此，不要包含专有/机密信息。不要超过所提供的空格。德克萨斯大学胃肠病学/肝病学研究培训项目的培训在消化和肝脏疾病部门的实验室以及德克萨斯大学西南医学中心和达拉斯退伍军人事务医学中心校园的几个基础科学系的实验室进行。在博士的指导下。John M. Dietschy, Stuart J. Spechler和Dwain L. Thiele，申请人经过仔细筛选和面试。每位成功申请者将在高级研究学院一名或多名成员的直接指导下进行一项主要研究项目，为期两至四年。此外，每位受训者将与其他高级研究学院和各个基础科学部门的成员密切互动。这些教员的实验室正在进行的项目非常多样化，涉及细胞和分子生物学的各种技术。代表性项目包括详细研究胆汁酸生物合成的其他生化途径的性质，孤儿核受体在控制胆汁酸合成和固醇运输中的作用，分析丙型肝炎的新治疗方法，细胞毒性淋巴细胞在肝炎和炎症性肠病等疾病中的作用以及新描述的胆固醇24羟化酶和ABCA1蛋白在胆道胆固醇分泌中的作用。最初，所有受训者都参加有关伦理生物学研究表现的正式讲座，并在全年参加该科的定期研究会议和临床会议。此外，还有为期两年的讲座，专门介绍胃肠道器官的生理学、分子生物学和细胞生物学。在这两到四年的密集研究工作课程中，学员将学习利用分子和细胞生物学中常见的各种基本实验室程序。如果受训者从事临床研究，他/她将参加为期一年的人体研究各方面的正式课程。所有受训者的进展都将被定期监测，在这段紧张的研究结束时，每个受训者也将有机会完成他/她的临床培训。有关于在医学研究中使用动物和人类伦理调查的特殊问题的正式课程。有一个积极的项目招收未被充分代表的少数民族。网站性能 ======================================== 节结束 ===========================================

BB Principal Investigator/Program Director (Last, first, middle): DIETSCHY. John Maurice DESCRIPTION. State the application's broad, long-term objectives and specific aims,making reference to the health relatednessofthe project. Describe concisely the research design and methods for achieving thaj^pals.Avoid summaries of past accomplishments and the^e of the first person. This description is meant to serve as a succinct and accurate description^^ie proposed work when separated from the applic^^fc If the application is funded, this description, as is, will become public information. Therefore, do not include proprietary/confidential information. DO NOT^CCEED THE SPACE PROVIDED. Training in the UT Gastroenterology/Hepatology Research Training Program takes place in the laboratories of the Division of Digestive and Liver Diseases and in the laboratories of several basic science departments at The University of Texas Southwestern Medical Center and the Dallas Veteran's Affairs Medical Center campuses. Under the direction of Drs. John M. Dietschy, Stuart J. Spechler and Dwain L. Thiele, applicants are carefully screened and interviewed. Each successful applicant will undertake a major research project for two to four years under the direct supervision of one or more members of the Senior Research Faculty. In addition, each trainee will have close interactions with other Senior Research Faculty and with members of various basic science departments. The projects that are ongoing in the laboratories of these faculty members are very diverse and involve a wide variety of techniques in cellular and molecular biology. Representative projects include detailed studies into the nature of alternative biochemical pathways for the biosynthesis of bile acids, the role of orphan nuclear receptors in the control of bile acid synthesis and sterol transport, an analysis of new treatments for hepatitis C, the role of cytotoxic lymphocytes in diseases such as hepatitis and inflammatory bowel disease and the role of newly described cholesterol 24 hydroxylase and the ABCA1 protein in biliary cholesterol secretion. Initially all trainees attend formal lectures in the performance of ethical biological research and,throughout the year, participate in regular research conferences and clinical conferences in the division. In addition, there is a two year cycle of lectures devoted to the physiology, molecular biology and cell biology of the organs of the gastrointestinal tract. Throughout this two to four year course of intense research work, the trainees will learn to utilize a variety of basic laboratory procedures common to molecular and cell biology. If the trainee is engaged in clinical investigation, he/she will participate in a year long formal course in various aspects of human research. The progress of all trainees is monitored on a regular basis and, at the end of this intense period of research, each trainee will also have the opportunity of completing his/her clinical training. There are formal courses in the use of animals in medical research and in the special problems of ethical human investigation. There is an active program for recruiting underrepresented minorities. PERFORMANCE SITE ========================================Section End===========================================