UT GASTROENTEROLOGY / HEPATOLOGY RESEARCH TRAINING PROGRAM

UT 胃肠病学/肝病学研究培训计划

• 批准号: 8877481
• 负责人: Ezra Burstein
• 金额: $ 24.34万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8877481
• 关键词: Gastroenterology; Hepatology; Research Training; Training Programs

DESCRIPTION (provided by applicant): The UT Gastroenterology / Hepatology research training program is aimed at producing the next generation of scientific leaders focused on understanding digestive and liver diseases. The program involves a variety of disciplines broadly categorized into two main areas: basic scientific research and patient-oriented clinical and translational research. The training program accepts primarily individuals with a background in Internal Medicine (M.D. or M.D./Ph.D. candidates), but also provides opportunities to trainees in Pediatrics, Surgery or Pathology. In addition, trainees without clinical training (Ph.D. candidates) are also part of our program. One unique characteristic is the inclusion of a significant proportion of minority trainees, primarily of Hispanic origin. Trainees benefit from a vast array of potential mentors including 35 Faculty that participate directly in this program, as well as a very rich milieu of scientific investigators across our campus. The scientific base of th training program includes research expertise in multiple areas critically important to the field such as mucosal immunology, microbial-host interactions, and inflammatory bowel disease; intestinal stem cells and malignant transformation in the GI tract, particularly the esophagus and colon; cancer prevention and screening; morphogenesis of the digestive system; obesity, liver steatosis, lipid metabolism and gallstone disease; immune responses in the liver and acute liver failure; hepatic fibrosis and portal hypertension; and, viral hepatitis and anti-viral immunity. Th training curriculum is flexible, but has two basic components. First, all of our trainees participae in a structured lecture series that highlights cutting edge research in fields of gastroenterology and hepatology. Similarly, a course in responsible conduct of research developed by the Graduate School of Biomedical Sciences is a core component of the training experience. In addition to core educational activities, direct training in research takes place primarily under th research mentor's guidance in a basic laboratory or as part of a clinical research group. Typically, our trainees devote 2 to 3 years to their research enterprise. The basic science training experience includes learning a variety of techniques in biochemistry, physiology, molecular biology and genetics, as well as participation in scientific meetings relevant to the particular discipline. On the other hand, clinical and translational research involves formal training in study design, including ethics and biostatics, through a Master's program in Clinical Science offered at our University. Finally, for our trainees with a clinical background in Internal Medicine, this research training program is integrated with our clinical fellowship in Gastroenterology and Hepatology, which includes a minimum of 18 months of dedicated clinical rotations. Therefore, in most instances the training period will last from 4 to 6 years for the fiv individuals for whom support is being requested. Altogether, this program is designed to train individuals who will be effective investigators and academic leaders in the fields of Gastroenterology and Hepatology.

描述（由申请人提供）：UT胃肠病学/肝病学研究培训计划旨在培养下一代专注于了解消化和肝脏疾病的科学领导者。该计划涉及各种学科，大致分为两个主要领域：基础科研和以患者为导向的临床和转化研究。该培训计划主要接受具有内科医学（M.D.）背景的个人。或医学博士/博士候选人），但也为儿科，外科或病理学的受训者提供机会。此外，未经临床培训的受训人员（博士）也是我们计划的一部分。一个独特的特点是包括相当大比例的少数族裔受训人员，主要是西班牙裔。学员将受益于大量潜在的导师，包括直接参与该项目的35名教师，以及我们校园内非常丰富的科学调查人员环境。th培训计划的科学基础包括多个领域的研究专业知识，这些领域对该领域至关重要，如粘膜免疫学，微生物-宿主相互作用和炎症性肠病;肠道干细胞和胃肠道恶性转化，特别是食管和结肠;癌症预防和筛查;消化系统的形态发生;肥胖，肝脏脂肪变性，脂质代谢和胆石病;肝脏中的免疫应答和急性肝衰竭;肝纤维化和门静脉高压;以及病毒性肝炎和抗病毒免疫。培训课程是灵活的，但有两个基本组成部分。首先，我们所有的学员都参加了一个结构化的系列讲座，重点介绍了胃肠病学和肝病学领域的前沿研究。同样，生物医学研究生院开发的负责任地进行研究的课程是培训经验的核心组成部分。除了核心教育活动，直接培训研究主要发生在研究导师的指导下，在基础实验室或作为临床研究小组的一部分。通常情况下，我们的学员将在他们的研究企业中投入2至3年的时间。基础科学培训经验包括学习生物化学，生理学，分子生物学和遗传学方面的各种技术，以及参加与特定学科相关的科学会议。另一方面，临床和转化研究涉及研究设计的正式培训，包括伦理学和生物统计学，通过我们大学提供的临床科学硕士课程。最后，对于具有内部临床背景的学员， 医学，这项研究培训计划与我们的胃肠病学和肝病学临床奖学金相结合，其中包括至少18个月的专门临床轮换。因此，在大多数情况下，培训期将持续4至6年的五个人的支持是请求。总之，该计划旨在培养个人谁将是有效的调查人员和学术领导人在胃肠病学和肝病学领域。