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WEIGHT, DEPRESSION AND FUNCTIONAL STATUS CHANGE PATHWAYS

体重、抑郁和功能状态变化途径

基本信息

批准号：
6963017
负责人：
VALERIE HOFFMAN
金额：
$ 6.64万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-01 至 2007-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The primary goal of the proposed study is to clarify the relationship between changes in weight and depression symptoms over time in the cohort of US adults enrolled in the Health and Retirement Study (HRS). The impact of functional status changes on the relationship between changes in weight and depression symptoms also will be assessed. This study has the following aims: 1. To determine the independent effects of (a) changes in depressive symptoms on changes in body mass index (BMI) and (b) changes in BMI on changes in depressive symptoms, after adjusting for baseline sociodemographic and behavioral factors and for changes in functional status. 2. To determine the degree to which the two relationships described above are modified by changes in functional status or other covariates. 3. To determine whether (a) change in BMI change directly affects change in depression symptom scores or whether the mechanism works indirectly through changes in functional status change and (b) change in depression symptom scores directly affects change in BMI or whether the mechanism works indirectly through functional status change. The immediate objective of the proposed research is to disentangle the relationship between weight and depression symptoms by studying the reciprocal relationship between changes in weight and changes in depression symptoms in the context of changes in functional status. These preliminary analyses will inform the development of future trials to rigorously test whether interventions targeted at reducing symptoms of depression can effectively treat obesity, whether interventions targeted at weight reduction can effectively treat depression, and whether these interventions must be tailored according to functional status. Dr. Hoffman is submitting this application as a new investigator.

描述（由申请人提供）：拟议研究的主要目的是阐明在健康与退休研究（HRS）的美国成年人队列中随时间的体重变化与抑郁症状之间的关系。还将评估功能状态变化对体重变化与抑郁症状之间关系的影响。本研究的目的如下：1。确定(a)抑郁症状变化对体重指数（BMI）变化的独立影响，(b) BMI变化对抑郁症状变化的独立影响，在调整基线社会人口统计学和行为因素以及功能状态变化后。2. 确定上述两种关系因功能状态或其他协变量的变化而改变的程度。3. 确定(a) BMI变化是否直接影响抑郁症状评分的变化或通过功能状态变化间接起作用；(b)抑郁症状评分的变化是否直接影响BMI变化或通过功能状态变化间接起作用。本研究的直接目的是在功能状态变化的背景下，通过研究体重变化与抑郁症状变化之间的相互关系，解开体重与抑郁症状之间的关系。这些初步分析将为未来试验的发展提供信息，以严格测试以减轻抑郁症状为目标的干预措施是否能有效治疗肥胖，以减轻体重为目标的干预措施是否能有效治疗抑郁症，以及这些干预措施是否必须根据功能状态量身定制。霍夫曼博士以新调查员的身份提交申请。