SocioEcological Impacts on Schistosomiasis Risk in Kenya

社会生态对肯尼亚血吸虫病风险的影响

• 批准号: 6931111
• 负责人: MARK L WILSON
• 金额: $ 6.46万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-15 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6931111
• 关键词: Africa; Schistosoma; clinical research; disease /disorder proneness /risk; ecology; epidemiology; geographic site; host organism interaction; human subject; parasitism; questionnaires; schistosomiasis; socioeconomics; statistics /biometry; water microbiology; water sampling /testing; zoonosis

DESCRIPTION (provided by investigator) Schistosomiasis affects roughly 200 million people worldwide, with at least 600 million being at risk. Although the biology of transmission is reasonably well understood, disease persists. Various social and economic factors are believed to influence environmental exposure, but few studies have carefully examined these variables as they affect infection in highly endemic regions. Those that have are mostly cross-sectional surveys that have limited ability to analyze these factors and relate them to time-space pattems of infection. We propose a prospective, case-control study designed to establish associations between socioeconomic factors and infection, determine whether socioeconomic factors contribute to re-infection risk, assess household-level spatial patterns of schistosomiasis as related to socioeconomic and ecologic risk factors, and calculate economic impacts of infection on households in Mbuani village, Coast Province, Kenya. Three aims involve a) determining how household-level socioeconomic factors influence host-environment interactions and hence contribute to individual infection and re-infection risk, b) evaluating whether different activity pattems in various land-cover environments are associated with schistosomiasis infection, and c) assessing the micro-economic impact of schistosomiasis infection among village residents. We will test consenting people for infection (treating those who are positive), ask questions about their activities and use of the local environment, and take ground and satellite-based data on the environment that will be analyzed by standard multivariate methods and spatial statistics. Our long-term goal is to produce information that can be used to direct control initiatives that will be effectively tailored to local socioeconomic and environmental dynamics.

描述（调查员提供）血吸虫病在全球大约有2亿人，至少有6亿人处于危险之中。尽管传播的生物学知识良好，但疾病仍然存在。人们认为各种社会和经济因素会影响环境暴露，但是很少有研究仔细检查这些变量，因为它们会影响高度流行地区的感染。那些大多数是横断面调查，它们能够分析这些因素并将其与感染的时空相关联。 我们提出了一项旨在建立社会经济因素和感染之间建立关联的前瞻性，病例对照研究，确定社会经济因素是否有助于重新感染风险，评估与社会经济经济和生态风险因素有关的家居水平的空间模式，并计算出米布维村的感染对家庭的经济影响。三个目的涉及a）确定家庭水平的社会经济因素如何影响宿主环境的相互作用，因此有助于个人感染和重新感染风险，b）评估各种土地环境中不同的活动pattems是否与血吸虫病感染相关，以及c）评估群疾病中的微观经济性感染者的微观经济影响。我们将测试人们感染的人（治疗那些积极的人），询问有关其活动和当地环境的使用问题，并在环境上获取基于卫星的数据，这些数据将通过标准的多元方法和空间统计数据进行分析。我们的长期目标是生成可用于控制将有效量身定制为当地社会经济和环境动态的信息。