New approaches to combating drug resistance via saturated chemical architectures

在这个合成化学项目中，我们研究了取代芳香族药物载体饱和碳氢化合物骨架的可行性，以此作为发现不太可能导致耐药性的新治疗药物的一种手段。随着对标准治疗方案反应不佳的疾病的出现，耐药性是一个日益严重的健康和经济问题。产生耐药性和药物失活的方式有很多种。开发克服这些途径的药物是当今的一个关键挑战。该项目的目的是开发新的饱和碳氢化合物化学合成方法，以扩大饱和笼状烃的可获得化学空间。将设计含苯药物的类似物，以评估这些结构修改如何影响失活的代谢途径。这项技术不仅在新药开发方面有潜在的应用，而且在新型聚合物、含能材料和催化剂的创新方面也有潜在的应用。

In this synthetic chemistry project we examine the feasibility of replacing aromatic pharmacophores saturated hydrocarbon frameworks as a means of discovering new therapeutic agents that are less likely to induce drug resistance. Drug resistance is an increasing health and economic concern with the emergence of diseases that respond poorly to standard treatment regimes. There are numerous ways by which drug resistance and drug deactivation can arise. The development of drugs that overcome these pathways is a key challenge today. The aims of this project are to develop new synthetic methods for the chemical synthesis of saturated hydrocarbon motifs to expand the accessible chemical space of saturated caged-hydrocarbons. Analogues of benzene-containing pharmaceuticals will be devised to assess how these structural modifications affect deactivating metabolic pathways. This technology does not only has potential applications in the development of new medicines, but also for the innovation of novel polymers, energetic materials and catalysts.