Core--Clinical Facility

核心--临床设施

• 批准号: 7014389
• 负责人: JAQUELYN F FLECKENSTEIN
• 金额: $ 11.92万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7014389
• 关键词: African American; biomedical facility; caucasian American; clinical research; cooperative study; hepatitis C; hepatitis C virus; human subject; medical outreach /case finding; racial /ethnic difference; tissue resource /registry

The Clinical Core of this proposal is an essential and integral part of the Memphis Cooperative Hepatitis C Research Center, without which the basic science projects would not be feasible. The projects utilize materials through the collaboration with one or more of the other groups, provided by the Clinical Core. Based on this, one could argue that the most important part of our Center is the Clinical Core. The strength of our Clinical Core is the ability of Drs. Fleckenstein and Riely and our nurse coordinator, Ms. Anne Madey, to recruit and retain AA patients. While no funds are requested to support patient treatment, the Clinical Core will continue to provide other tissue samples for the analyses detailed in Projects 1 and 2. One of the major limitation into research that could lead to an understanding of the difference in response to therapy between AA and non AA is the relatively low numbers of AA included in most studies to date. As a single center, we have been enormously successful in recruiting AA patients and obtaining materials for our studies. While the basic science projects are absolutely dependent upon the Clinical Core to provide the necessary patient samples to complete the proposed studies, the Clinical Core is also dependent upon the research projects to support and justify the need to recruit patients that meet criteria important to the research projects within the guidelines of NIH mandated Human Use Policy. Activities of the Clinical Core will also be supported by the UTHSC General Clinical Research Center without which all of the necessary laboratory tests required for each patient would be difficult to acquire.

这项提案的临床核心是孟菲斯合作社必不可少的组成部分 丙型肝炎研究中心，没有这个中心，基础科学项目就不可行。这些项目通过与临床核心提供的一个或多个其他小组合作来利用材料。基于此，有人可能会说，我们中心最重要的部分是临床核心。我们临床核心的优势在于Fleckenstein博士和Riely博士以及我们的护士协调员Anne Madey女士招募和留住AA患者的能力。虽然不要求任何资金来支持患者的治疗，但临床核心将继续提供 项目1和2中详细说明的用于分析的其他组织样本。可能导致对治疗反应的差异的理解的研究的主要限制之一 在AA和非AA之间是迄今为止大多数研究中包含的相对较低的AA数量。作为一个单一的中心，我们在招募再生障碍性贫血患者和获取研究材料方面取得了巨大的成功。虽然基础科学项目绝对依赖于临床核心来提供必要的患者样本来完成拟议的研究，但临床核心也依赖于研究项目来支持和证明有必要招募符合NIH强制人类使用政策指南中对研究项目重要的标准的患者。临床核心的活动还将得到UTHSC综合临床研究中心的支持，如果没有该中心，将很难获得每个患者所需的所有必要的实验室测试。