Core--Clinical Facility

本提案的临床核心是孟菲斯合作社的重要组成部分 丙型肝炎研究中心，没有它的基础科学项目将是不可行的。这些项目通过与临床核心提供的一个或多个其他小组合作来利用材料。基于这一点，人们可以说，我们中心最重要的部分是临床核心。我们的临床核心的力量是博士的能力. Fleckenstein和Riely和我们的护士协调员，女士.安妮Madey，招募和留住AA患者.虽然没有资金被要求支持病人的治疗，临床核心将继续提供 用于项目1和2中详述的分析的其他组织样本。一个主要的限制进入研究，可能导致理解的差异，反应的治疗 AA和非AA之间的差异是迄今为止大多数研究中纳入的AA数量相对较低。作为一个单一的中心，我们在招募AA患者和获得研究材料方面取得了巨大的成功。虽然基础科学项目完全依赖于临床核心来提供必要的患者样本以完成拟定研究，但临床核心也依赖于研究项目来支持和证明招募符合NIH强制性人类使用政策指南内研究项目重要标准的患者的必要性。临床中心的活动也将得到UTHSC综合临床研究中心的支持，没有该中心，将难以获得每位患者所需的所有必要实验室检查。

The Clinical Core of this proposal is an essential and integral part of the Memphis Cooperative Hepatitis C Research Center, without which the basic science projects would not be feasible. The projects utilize materials through the collaboration with one or more of the other groups, provided by the Clinical Core. Based on this, one could argue that the most important part of our Center is the Clinical Core. The strength of our Clinical Core is the ability of Drs. Fleckenstein and Riely and our nurse coordinator, Ms. Anne Madey, to recruit and retain AA patients. While no funds are requested to support patient treatment, the Clinical Core will continue to provide other tissue samples for the analyses detailed in Projects 1 and 2. One of the major limitation into research that could lead to an understanding of the difference in response to therapy between AA and non AA is the relatively low numbers of AA included in most studies to date. As a single center, we have been enormously successful in recruiting AA patients and obtaining materials for our studies. While the basic science projects are absolutely dependent upon the Clinical Core to provide the necessary patient samples to complete the proposed studies, the Clinical Core is also dependent upon the research projects to support and justify the need to recruit patients that meet criteria important to the research projects within the guidelines of NIH mandated Human Use Policy. Activities of the Clinical Core will also be supported by the UTHSC General Clinical Research Center without which all of the necessary laboratory tests required for each patient would be difficult to acquire.