Humoral And Cellular Tolerization Approaches Against Au*

描述(由申请人提供)： 在仔细评估了迄今为止提出的治疗自身免疫性疾病的策略的优点、潜在缺陷、担忧和失败后，得出的结论是，重组抗体和基于树突状细胞的方法将是临床上可移植的方法，在治疗期间成功的可能性最大，同时最不担心有害的副作用。重要的是，参与这一提议的研究人员自己或正在与匹兹堡大学的其他人合作，这些人在这些方法方面拥有非凡的专业知识。这项申请将进一步深入了解拟议办法的基本行动机制，这本身就是选择和评价这些办法的一个令人信服的理由。为了更好地组织这些研究，还得出结论，自动免疫卓越中心可能是整合匹兹堡大学感兴趣的临床医生和科学家的努力的最合适的“保护伞”。研究和开发治疗自身免疫性疾病的新治疗方法的复杂性需要一个现代的、多学科的研究氛围。为了以最具成本效益和学术效率的方式最大限度地利用所有资源，该大学内对同一科学领域感兴趣的研究人员之间的专业知识和现有技术的同步是必要的。此外，匹兹堡大学将从专门致力于自身免疫研究的论坛中受益匪浅，在该论坛上，不同部门和机构的初级和资深研究人员，以及具有跨学科专业知识的人，可以与感兴趣的临床医生聚集在一起，以便更有效地促进从病床到床边的转移。为了鼓励年轻的研究人员致力于自身免疫性疾病的研究，特别是那些影响儿童的疾病，这里建议建立一个自身免疫卓越中心，并坚信在一个具有科学挑战性的合作和知识话语的氛围中，培养这种类型的职业更容易。最后，匹兹堡的自身免疫卓越中心完全致力于一个单一的哲学和科学目标：“了解、预防并最终治愈自身免疫性疾病”将允许创造新的科学线索，这些线索将构成更有前途的临床试验的基础。

DESCRIPTION (provided by applicant): After carefully evaluating the merits, potential pitfalls, concerns and failures of the strategies so far proposed to treat autoimmune diseases, it was concluded that recombinant antibody and dendritic cell-based approaches would be clinically translatable modalities with the greatest likelihood of success during treatment, combined with the least concern of deleterious side effects. Importantly, the investigators collaborating in this proposal have themselves, or are collaborating with others at the University of Pittsburgh who have exceptional expertise in these approaches. This application will provide further insights into the basic mechanisms of action of the proposed approaches, in itself a compelling rationale for their selection and evaluation. To better organize these studies, it was also concluded that an Autoimmunity Center of Excellence may represent the most appropriate "umbrella" under which to consolidate the efforts of the interested clinicians and scientists of the University of Pittsburgh. The complexity of studying and developing new therapeutic approaches to treating autoimmune diseases requires a modern, multidisciplinary research climate. The synchronization of both the expertise and the technology available among the investigators within this university who are interested in the same scientific area, i.e., autoimmunity, is necessary in order to maximize the use of all of the resources in the most cost effective and academically efficient manner. Moreover the University of Pittsburgh will greatly benefit from a forum specifically dedicated to the study of autoimmunity, where both junior and established investigators within different departments and institutions, and with interdisciplinary expertise, can be drawn together with interested clinicians so that bench-to-bedside transfer can be fostered more efficiently. In order to encourage young researchers to devote their careers to the study of autoimmune ailments, especially those that affect children, it is here proposed to build an Autoimmune Center of Excellence with the specific belief that fostering of this type of career is easier within a scientifically challenging atmosphere of collegiality and intellectual discourse. Finally, having an Autoimmunity Center of Excellence in Pittsburgh entirely dedicated to a single philosophical and scientific goal: "understanding, preventing and eventually curing autoimmune diseases" will allow the creation of new scientific leads that will form the basis for more promising clinical trials.