CORE--TISSUE PROCUREMENT /DATA ANALYSIS /SERUM ANALYSIS

核心B的总体目标是为项目1-4的研究者提供定义良好的组织样本，并维护一个完整准确的交互式数据库。核心B获取组织并提供数据管理以支持项目。血液和粘膜样本经过处理以供实验使用和/或储存，并收集相关临床数据并输入临床数据库。组织样本与供体的临床和家族特征数据相匹配，并与相关的免疫和遗传参数交叉参考。采购技术人员在医生就诊时从临床和研究患者处收集样本，参加内窥镜程序以获取活检材料，并与医院外科医生和病理学家协调，从肠切除术中获取粘膜样本。试验将用于检测从项目研究或外部合作收集的所有新小鼠和人血清中的微生物抗原抗体。临床数据和基础科学研究的结果进行了协调，以便根据各种临床、亚临床、遗传和流行病学参数对人群进行分层。核心B提供的服务随着数据管理职责的增加而扩大，包括数据库管理和用于数据展示和实验开发的统计服务。该中心鼓励多名调查人员使用同一名捐赠者的样本。核心服务进一步扩展到临床试验支持、临床研究协调和转化等方面。两个

The overall goal of Core B is to provide investigators of Projects 1-4 with well-defined tissue samples, and maintain a complete and accurate interactive database. Core B obtains the tissues and provides data management in support of the projects. Blood and mucosal samples are processed for experimental use and/or storage, and associated clinical data is gathered and entered into the clinical database. Tissue samples are matched with clinical and familial trait data from the donor cross-referenced with associated immunologic and genetic parameters. The procurement technician collects samples from clinical and research study patients at physician visits, attends endoscopic procedures to procure biopsy material and coordinates with hospital surgeons and pathologists to obtain mucosal samples from intestinal resections. Assays will be run to detect antibodies to microbial antigens on all new mouse and human sera collected from program project research or outside collaborations. Clinical data and results from basic science studies are coordinated to allow stratification of populations by a variety of clinical, subclinical, genetic and epidemiologic parameters. The services provided by Core B have expanded with the increase in data management responsibilities to include database management and statistical services for data presentation and experimental development. The Core encourages use of samples from one donor by several investigators. Core services have been further expanded to clinical trial support, and coordination and translational aspects of clinical research. Two physicians are included among the Core personnel and additional clinical services will be provided in cooperation with the Cedars-Sinai General Clinical Research Center. The Research Studies Coordinator will help to identify study populations, provide masking and randomization schemes. Statistical analysis is also provided.