CORE--TISSUE PROCUREMENT & DATA ANALYSIS & SERUM ANALYSIS

核心——纸巾采购

• 批准号: 7487329
• 负责人: Stephan R. Targan
• 金额: $ 22.54万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7487329
• 关键词: Antibodies; Basic Science; Biological Assay; Biopsy; Blood; Blood Cells; Cells; Characteristics; Clinical; Clinical Data; Clinical Research; Clinical Services; Clinical Trials; Collaborations; Correlation Studies; Data; Data Analyses; Data Collection; Databases; Development; Ensure; Excision; Genetic; Goals; Hospitals; Human; Human Resources; Immunologics; Intestines; Masks; Mesentery; Mus; Numbers; Operative Surgical Procedures; Pathologist; Patients; Physicians; Population; Population Study; Positioning Attribute; Preparation; Procedures; Process; Program Research Project Grants; Purpose; Randomized; Relative (related person); Research; Research Personnel; Running; Sampling; Scheme; Serological; Serum; Services; Specimen; Stratification; Surgeon; Tissue Banks; Tissue Procurements; Tissue Sample; Tissues; Visit; Work; base; data management; microorganism antigen; programs; research study; statistical service; trait; trend

The overall goal of Core B is to provide investigators of Projects 1-4 with well-defined tissue samples, and maintain a complete and accurate interactive database. Core B obtains the tissues and provides data management in support of the projects. Blood and mucosal samples are processed for experimental use and/or storage, and associated clinical data is gathered and entered into the clinical database. Tissue samples are matched with clinical and familial trait data from the donor cross-referenced with associated immunologic and genetic parameters. The procurement technician collects samples from clinical and research study patients at physician visits, attends endoscopic procedures to procure biopsy material and coordinates with hospital surgeons and pathologists to obtain mucosal samples from intestinal resections. Assays will be run to detect antibodies to microbial antigens on all new mouse and human sera collected from program project research or outside collaborations. Clinical data and results from basic science studies are coordinated to allow stratification of populations by a variety of clinical, subclinical, genetic and epidemiologic parameters. The services provided by Core B have expanded with the increase in data management responsibilities to include database management and statistical services for data presentation and experimental development. The Core encourages use of samples from one donor by several investigators. Core services have been further expanded to clinical trial support, and coordination and translational aspects of clinical research. Two physicians are included among the Core personnel and additional clinical services will be provided in cooperation with the Cedars-Sinai General Clinical Research Center. The Research Studies Coordinator will help to identify study populations, provide masking and randomization schemes. Statistical analysis is also provided.

核心B的总体目标是向项目1-4的研究人员提供定义明确的组织样本，并保持完整而准确的交互式数据库。核心B获得组织并提供数据管理以支持项目。处理血液和粘膜样品以进行实验用途和/或存储，并收集相关的临床数据并输入到临床数据库中。组织样品与来自与相关的免疫和遗传参数交叉引用的供体的临床和家族性状数据相匹配。采购技术人员从医师就诊时从临床和研究研究患者那里收集样本，参加内窥镜手术以采购活检材料，并与医院外科医生和病理学家进行坐标，以从肠道切除术中获取粘膜样本。将进行测定以检测从计划研究或外部协作中收集的所有新老鼠和人类血清的微生物抗原抗体。临床数据和基础科学研究的结果是协调的，以允许通过各种临床，亚临床，遗传和流行病学参数对种群进行分层。核心B提供的服务随着数据管理职责的增加而扩展，包括数据库管理和统计服务，以进行数据显示和实验开发。核心鼓励使用几位调查人员从一个捐助者那里使用样品。核心服务已进一步扩展到临床试验支持，临床研究的协调和翻译方面。二 医师包括在核心人员中，将与Cedars-Sinai一般临床研究中心合作提供其他临床服务。研究研究协调员将有助于确定研究人群，提供掩盖和随机方案。还提供了统计分析。